Campo-Deaño, Laura

Carneiro, J.

Oliveira, Monica

Pinho, F.T.

Name not available

Numerical and experimental in-vitro analysis of blood flow through middle cerebral aneurysms

University of Strathclyde Institutional Repository

Strathprints Institutional RepositoryCampo-Deaño, Laura and Carneiro, J. and Oliveira, Monica and Pinho, F.T. (2014) Numerical and experimental in-vitro analysis of blood flow through middle cerebral aneurysms. In: 9th Annual European Rheology Conference, AERC 2014, 2014-04-08 - 2014-04-11. , This version is available at http://strathprints.strath.ac.uk/47502/Strathprints is  designed  to  allow  users  to  access  the  research  output  of  the  University  of Strathclyde. Unless otherwise explicitly stated on the manuscript, Copyright © and Moral Rights for the papers on this site are retained by the individual authors and/or other copyright owners. Please check the manuscript for details of any other licences that may have been applied. You may  not  engage  in  further  distribution  of  the  material  for  any  profitmaking  activities  or  any commercial gain. You may freely distribute both the url (http://strathprints.strath.ac.uk/) and the content of this paper for research or private study, educational, or not-for-profit purposes without prior permission or charge. Any  correspondence  concerning  this  service  should  be  sent  to  Strathprints  administrator: strathprints@strath.ac.ukNumerical and experimental in-vitro analysis of blood flow through middle cerebral aneurysms  Laura Campo-Deaño1, João Carneiro1, Mónica S. N. Oliveira2 and Fernando T. Pinho1 1 FEUP, Faculdade de Engenharia da Universidade do Porto, 4200-465 Porto, Portugal 2 James Weir Fluids Laboratory, Department of Mechanical and Aerospace Engineering, University of Strathclyde, Glasgow G1 1XJ, United Kingdom   Cerebral aneurysms are one of the most common cerebrovascular accidents and are the cause of one-third of deaths worldwide [1]. This kind of accidents starts with a dilatation of an artery usually occurring near arterial bifurcations in the Circle of Willis [2,3]. Despite growing progress, the initiation, growth and rupture of aneurysms are still not well understood. Computational Fluid Dynamics (CFD) has been progressively used for modelling the flow in diseased arteries and it is a tool of great potential for the diagnostic, prediction and treatment of cerebral aneurysms [4]. In this work we numerically and experimentally investigate the hemodynamics in simplified geometries representative of middle cerebral aneurysms. Three geometries are considered consisting of different bifurcations with an aneurysm located at the end of the parent vessel in which the neck of the aneurysm and the shape of the daughter branches are varied, but all vessel walls are flat to allow easy optical assess in the experiments. For the computations, two different viscoelastic models, namely the Giesekus and sPTT models were used based on fitting the rheology of real human blood to these models [5]. The numerical results were compared with velocity profiles obtained experimentally by means of micro-Particle Image Velocimetry measurements carried out in the different aneurysm configurations using blood analogue solutions recently developed by the group [5].  [1] C. Deaton, E. S. Froelicher, L. H. Wu, C. Ho, K. Shishani, T. Jaarsma. The Journal of Cardiovascular Nursing 26 (2011) S5̽14. [2] J. C. Lasheras. Annual Review of Fluid Mechanics 39 (2007) 293̽319. [3] D. M. Sforza, C. M. Putman, J. R. Cebral. Annual Review of Fluid Mechanics 41 (2009) 91̽107. [4] L. Campo-Deaño, M. S. N. Oliveira and F.T. Pinho. (2014) submitted. [5] L. Campo-Deaño, R. P. A. Dullens, D. G. L. A. Aarts, F. T. Pinho, M. S. N. Oliveira. Biomicrofluidics 7 (2013) 034102.   

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Numerical and experimental in-vitro analysis of blood flow through middle cerebral aneurysms

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