Double Blind parallel randomized clinical trial to demonstrate the effects of metfomin in insulin treated patient

Aviles-Santa L

Bastyr EJ

Calle-Pascual AL

Campbell IW

Cefalu WT

Cockroft DW

DeFronzo RA

Diabetes Prevention Program Research Group.

Dornan TL

Dunn CJ

Fanghanel G

Frison L

Gans RO

Giugliano D

Grant PJ.

Horton ES

Jackson RA

Johnson JA

Kannel WB

Landin K

Melchior WR

Nagi DK

Nielsen FS

O'Brien E

Prospective UK Diabetes Study (UKPDS) Group.

Ridray S.

Robinson AC

Schafers RF.

Schneider J.

Sechi LA

Sundaresan P

Tack CJ

van Binsbergen JHGLMG

Wulffele MG

Yki-Jarvinen H

Yu JG

Wulffele, M.G.

Kooy, A

Lehert, P.

Bets, D.

Donker, A.J.M.

DSpace at VU

Does metformin decrease blood pressure in patients with Type 2 diabetes intensively treated with insulin?

We investigated in a double-blind study whether metformin reduces blood pressure (BP) in patients with Type 2 diabetes intensively treated with insulin. 220 patients with Type 2 diabetes were asked to undergo 24-h ambulatory BP monitoring (24-h ABPM). Systolic BP (SBP), diastolic BP (DBP), pulse BP (PP), mean BP (MP) and heart rate (HR) were measured as office BP measurements and as 24-h ABPM for 24-h, day and night. Office BP measurements did not differ significantly between the placebo- and metformin-treated groups for any BP measure, but showed a non-significant trend for SBP reduction with metformin use (mean baseline-adjusted difference, metformin minus placebo: -4.2 mmHg, 95% CI, -9.9 to +1.5; P = 0.15).Conclusion: Metformin does not significantly affect BP in patients with Type 2 diabetes intensively treated with insulinEssai en double aveugle de réduction de la tension artérielle dans les patients présentant le type 2 diabète insulino-dependant. 220 patients présentant le type 2 diabète ont été invités à la mesure de pression ambulatoire. La tension systolique (SBP et diastolique (DBP), et la fréquence cardiaque (heure) ont été mesurés. Les mesures n'ont pas différé de manière significative entre le placebo et les groupes metformin-traités (delta=-4.2 mmHg, 95% CI, -9.9 to +1.5; P = 0.15

Wulffele, M.G

Stehouwer, C

Donker, A

Lehert, Philippe

DIAL UCLouvain

Does metformin decrease blood pressure in patients with Type 2 diabetes intensively treated with insulin.

NARCIS 

Stehouwer, CD

Donker, AJ

Does metformin decrease blood pressure in patients with Type 2 diabetes intensively treated with insulin ?

AIMS: We investigated in a double-blind study whether metformin reduces blood pressure (BP) in patients with Type 2 diabetes intensively treated with insulin. METHODS: A total of 220 patients with Type 2 diabetes were asked to undergo 24-h ambulatory BP monitoring (24-h ABPM). One hundred and eighty-two gave informed consent. Eighty-nine were randomized to metformin and 93 to placebo. Thirty-five subjects dropped out (13 placebo, 22 metformin users); 147 patients underwent a second 24-h ABPM, 16 weeks after randomization. RESULTS: Systolic BP (SBP), diastolic BP (DBP), pulse BP (PP), mean BP (MP) and heart rate (HR) were measured as office BP measurements and as 24-h ABPM for 24-h, day and night. Office BP measurements did not differ significantly between the placebo- and metformin-treated groups for any BP measure, but showed a non-significant trend for SBP reduction with metformin use (mean baseline-adjusted difference, metformin minus placebo: -4.2 mmHg, 95% CI, -9.9 to +1.5; P = 0.15). The baseline-adjusted differences of the ambulatory measurements were -0.2 mmHg (95% CI, -2.9 to +2.6) for the 24-h SBP, and +1.1 mmHg (95% CI, -0.7 to +2.8) for the 24-h DBP. On the whole, BP differences between metformin- and placebo-treated groups were not statistically significant. The only significant difference was for night-time PP (baseline-adjusted difference: -2.2 mmHg; 95% CI, -4.2 to -0.2). These results were not different after adjustment for age and diabetes duration, or for (changes in) body mass index, glycated haemoglobin, insulin dose or plasma homocysteine. CONCLUSION: Metformin does not significantly affect BP in patients with Type 2 diabetes intensively treated with insulin

Kooy, A.

Donker, A.J.

Stehouwer, C.D.

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Does metformin decrease blood pressure in patients with Type 2 diabetes intensively treated with insulin?

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