Dijkstra, C.D. [Promotor]Ploegh, H.L. [Promotor

Abdi, K.

DSpace at VU

 
 
 
 
 
IL-12: The Role of p40 versus p75 
 
 
 
 
 
 
 
 
 
 
 
 
 
Kaveh Abdi 
 
 
 
 
 
 
 
 
 
 
 
The research described in this thesis was performed: 
In the Laboratory of Cellular Immunology Genetics Institute 
Cambridge Massachusetts, Harvard Medical School Boston 
Massachusetts, and Laboratory of Cellular and Molecular 
Immunology, supported by the intramural program of the National 
Institute of Allergy and Infectious Diseases, National Institute of 
Health, Bethesda, Maryland USA. 
 
IL-12: The Role of p40 versus p75 
 
 
Kaveh Abdi 
 
Table of Contents 
           Page 
 
Summary Dutch/English 
  
Preface          I-V 
 
Introduction         1-24 
 
Chapter-I Hypothesis: IL-12: The Role of p40 versus p75                   25 
K. Abdi Scand. J. of Immunol. 2002 July; 56(1):1-11. 
 
Chapter-II  CTL generation in the presence of IL-4 is inhibited by free 
p40: evidence for early and late IL-12 function.  
K. Abdi & S. Herrmann The Journal of Immunology, 1997, 
159:3148                 37 
 
Chapter-III T–cell Control of IL-12p75 Production     
K. Abdi, N. Singh & P. Matzinger  
“Frontlines” Scand. J. of Immunol. 2006 Aug; 64(2): 83 92   47 
 
Chapter-IV T cell-dependent IFN-γ-Independent Pathways of IL-12p75 
Production Kaveh Abdi               59 
 
Chapter-V  LPS Activated Dendritic cells: “Exhausted” or alert and 
waiting Kaveh Abdi              89 
 
Discussion                  111 
 
Acknowledgement                                                                                  132 
 
Curriculum Vitae                         133 
_____________________________________________________ 


IL-12: The Role of p40 versus p75

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VU Research PortalIL-12: The Role of p40 versus p75Abdi, K.2010document versionPublisher's PDF, also known as Version of recordLink to publication in VU Research Portalcitation for published version (APA)Abdi, K. (2010). IL-12: The Role of p40 versus p75.General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.            • Users may download and print one copy of any publication from the public portal for the purpose of private study or research.            • You may not further distribute the material or use it for any profit-making activity or commercial gain            • You may freely distribute the URL identifying the publication in the public portal ?Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.E-mail address:vuresearchportal.ub@vu.nlDownload date: 23. May. 2021IL-12p75Danger and/or PAMPsThe Inflammatory SoupChemokinesHistamineKinin systemClotting factorsSerotoninCytokinesComplement systempXpXIs P40 present? IIsPP4400ppresentt??formation of p40 dimersIL-X OrIL-YTIL-23p59p40+pXorp40 + pYpYpX?APCAPCdd//////APCPRRpp40 pYKaveh AbdiIL-12: The Role of p40 vs p75IL-12: The Role of p40 vs p75                                                                                Kaveh AbdiOmslag -1.indd   1Omslag -1.indd   17-4-2010   11:44:197-4-2010   11:44:19

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