Schoffelmeer, A.N.M. [Promotor]Pattij, T. [Copromotor

Wiskerke, J.

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Cannabinoid and opioid modulation of impulsive behavior and drug addiction

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VU Research PortalCannabinoid and opioid modulation of impulsive behavior and drug addictionWiskerke, J.2013document versionPublisher's PDF, also known as Version of recordLink to publication in VU Research Portalcitation for published version (APA)Wiskerke, J. (2013). Cannabinoid and opioid modulation of impulsive behavior and drug addiction.General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.            • Users may download and print one copy of any publication from the public portal for the purpose of private study or research.            • You may not further distribute the material or use it for any profit-making activity or commercial gain            • You may freely distribute the URL identifying the publication in the public portal ?Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.E-mail address:vuresearchportal.ub@vu.nlDownload date: 21. May. 2021Cannabinoid a n d  o p i o i d m o d u l a t i o n of impulsive b e h a v i o r a n d  d r u g addictionJ o o s t  W i s k e r k e©Occasionally, it happens to all of us: you speak out of turn during a meeting or you make a comment and immediate realize that you shouldn’t have said it. Or you buy an expensive pair of shoes even though you actually cannot afford them. Two examples of daily-live impulsive behavior, and more specifically of impulsive action (acting without foresight) and impulsive choice (acting with disregard of long-term consequences), respectively. When somebody is hyper-impulsive, this personality trait can negatively affect that person’s life. Failure to suppress impulsive behavior (failing impulse-control) is a well-known endophenotype in people suffering from Attention-Deficit/Hyperactivity Disorder (ADHD) or drug addiction, but also for instance in people with a bipolar disorder (during the manic phases). Hyper-impulsivity results from abnormal brain functioning. However, the exact malfunctions in the ‘impulsive brain’ to date remain largely unknown, thereby hampering effective treatment of this maladaptive behavior. An important aim of this Ph.D. thesis was to gain more insight in the neurobiology of impulsivity. In addition, this thesis examines some aspects of the neurobiology of drug addiction, a psychiatric disorder that, as mentioned before, is in most patients characterized by impulse control-related problems, particularly during the abstinence phase when drug addicts have been drug-free for some time and try to prevent relapse. By using rat behavioral models combined with various pharmacological approaches, we have studied the neurobiology of impulsivity and relapse to drug seeking, in search of putative ‘targets’ for novel medication against hyper-impulsivity and/or drug addiction. Thereby, we focused specifically on the cannabinoid and opioid neurotransmitter systems.Cannabinoid a n d  o p i o i d m o d u l a t i o n of impulsive b e h a v i o r a n d  d r u g addictionUitnodigingVoor het bijwonen van de openbare verdediging van mijn proefschrift:Cannabinoid and opioid modulation of impulsive behavior and drug addictionOp donderdag 14 maart 2013 om 13:45 uur in de aula van het hoofdgebouw van de Vrije Universiteit, De Boelelaan 1105, Amsterdam.Receptie na afloop.Joost WiskerkeContact:joost.wiskerke@gmail.comParanimfen:Anouk den Braber (a.den.braber@vu.nl)Jelte Wouda (jeltewouda@gmail.com)Cannabinoid and opioid modulation of impulsive behavior and drug addictionJoost Wiskerkesnij-lijnen in documentCoverdesign2.0.indd   1 22-1-2013   21:41:56

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Cannabinoid and opioid modulation of impulsive behavior and drug addiction

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