Scheltens, P. [Promotor]Lammertsma, A.A. [Promotor]Berckel, B.N.M. van [Copromotor]Flier, W.M. van der [Copromotor

Tolboom, N.

DSpace at VU

Imaging Alzheimer’s disease 
pathology in vivo:  
towards an early diagnosis
Nelleke Tolboom
Im
aging A
lzheim
er’s disease pathology in vivo: tow
ards an early diagnosis 
N
elleke Tolboom
Over the past two decades, positron emission tomography 
(PET) tracers have been developed for in vivo visualisation 
and quantification of Alzheimer’s disease (AD) pathology. 
Previously, detection of AD pathology was only possible at 
post mortem examination of the brain or at brain biopsy. 
The possibility to image the amount and distribution of AD 
pathology during life has initiated a new research area. It shows 
promise to facilitate early and accurate diagnosis of AD, provide 
more insight in the time course and regional deposition of 
pathology during life and assist in the development of potential 
treatments. This thesis is dedicated to evaluate and compare 
the performance of two promising ligands for in vivo imaging of 
AD pathology, [11C]PIB and [18F]FDDNP.
nelleke tolboom omslag.indd   1 28-12-2009   09:39:04


Imaging Alzheimer's disease pathology in vivo: towards an early diagnosis

VU Research Portal

VU Research PortalImaging Alzheimer's disease pathology in vivoTolboom, N.2010document versionPublisher's PDF, also known as Version of recordLink to publication in VU Research Portalcitation for published version (APA)Tolboom, N. (2010). Imaging Alzheimer's disease pathology in vivo: towards an early diagnosis.General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.            • Users may download and print one copy of any publication from the public portal for the purpose of private study or research.            • You may not further distribute the material or use it for any profit-making activity or commercial gain            • You may freely distribute the URL identifying the publication in the public portal ?Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.E-mail address:vuresearchportal.ub@vu.nlDownload date: 23. May. 2021Imaging Alzheimer’s disease pathology in vivo:  towards an early diagnosisNelleke TolboomImaging Alzheimer’s disease pathology in vivo: towards an early diagnosis Nelleke TolboomOver the past two decades, positron emission tomography (PET) tracers have been developed for in vivo visualisation and quantification of Alzheimer’s disease (AD) pathology. Previously, detection of AD pathology was only possible at post mortem examination of the brain or at brain biopsy. The possibility to image the amount and distribution of AD pathology during life has initiated a new research area. It shows promise to facilitate early and accurate diagnosis of AD, provide more insight in the time course and regional deposition of pathology during life and assist in the development of potential treatments. This thesis is dedicated to evaluate and compare the performance of two promising ligands for in vivo imaging of AD pathology, [11C]PIB and [18F]FDDNP.nelleke tolboom omslag.indd   1 28-12-2009   09:39:04

English