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research
MEG resting state functional connectivity in Parkinson's disease related dementia
Authors
A Hadjipapas
A Schnitzler
+57 more
AF Leuchter
American Psychiatric Association
C Babiloni
C Babiloni
C Besthorn
C Hammond
C Junque
C. J. Stam
CF Lippa
CJ Stam
CJ Stam
CJ Stam
CJ Stam
CJ Stam
CW Tam
D Osipova
D Stoffers
D. Stoffers
DP Holschneider
E Londos
E Pereda
E. Ch. Wolters
EJ Burton
F Bartolomei
F Varela
H Braak
H. W. Berendse
HW Berendse
J Gross
J Jankovic
J. L. W. Bosboom
JL Bosboom
JM Candy
KM Cullen
KS Cover
M Kikuchi
MF Folstein
O David
O Pogarell
OJ Vogels
P Broks
P Fries
P Silberstein
PJ Uhlhaas
R Camicioli
R Franciotti
RL Buckner
S Fahn
S Lehericy
T Gasser
T Koenig
T Locatelli
T Montez
T Sunderland
TC Buter
WR Gibb
YA Pijnenburg
Publication date
1 January 2008
Publisher
Doi
Cite
Abstract
Parkinson's disease (PD) related dementia (PDD) develops in up to 60% of patients, but the pathophysiology is far from being elucidated. Abnormalities of resting state functional connectivity have been reported in Alzheimer's disease (AD). The present study was performed to determine whether PDD is likewise characterized by changes in resting state functional connectivity. MEG recordings were obtained in 13 demented and 13 non-demented PD patients. The synchronization likelihood (SL) was calculated within and between cortical areas in six frequency bands. Compared to non-demented PD, PDD was characterized by lower fronto-temporal SL in the alpha range, lower intertemporal SL in delta, theta and alpha1 bands as well as decreased centro-parietal gamma band synchronization. In addition, higher parieto-occipital synchronization in the alpha2 and beta bands was found in PDD. The observed changes in functional connectivity are reminiscent of changes in AD, and may reflect reduced cholinergic activity and/or loss of cortico-cortical anatomical connections in PDD. © 2008 The Author(s)
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