Delemarre-van De Waal, H.A. [Promotor]Leeuwen, F.E. van [Promotor]Weissenbruch, M.M. van [Copromotor]Vermeiden, J.P.W. [Copromotor

Ceelen, M.

NARCIS 

Growth and Development of Children born after IVF Treatment

VU Research Portal

VU Research PortalGrowth and Development of Children born after IVF TreatmentCeelen, M.2009Link to publication in VU Research Portalcitation for published version (APA)Ceelen, M. (2009). Growth and Development of Children born after IVF Treatment. Ceelen.General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright ownersand it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.            • Users may download and print one copy of any publication from the public portal for the purpose of private study or research.            • You may not further distribute the material or use it for any profit-making activity or commercial gain            • You may freely distribute the URL identifying the publication in the public portal ?Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediatelyand investigate your claim.E-mail address:vuresearchportal.ub@vu.nlDownload date: 23. May. 2021Growth and Developmentof Children born after IVF TreatmentManon CeelenGrowth and Development of Children born after IVF Treatment                                                             Manon CeelenDuring the past decades, in vitro fertilization (IVF) has become a routine procedure in reproductive medicine to overcome subfertility problems in couples all over the world. Since the first IVF birth in 1978, an estimated three million children have been born worldwide after IVF or related assisted reproductive technologies. Nowadays, there is a substantial body of evidence that IVF children are at increased risk for adverse perinatal outcome. In addition, various studies suggested an increased incidence of congenital abnormalities and rare imprinting diseases among IVF children. Nevertheless, several studies indicated that IVF children do not differ from spontaneously conceived controls in terms of mental and psychomotor development. There is still no consensus on whether observed health problems are related to the IVF procedure itself, the underlying subfertility problems of the parents, or a combination. Due to the lack of systematic follow-up of these children during the past years, it is largely unclear whether IVF treatment in humans is associated with substantial developmental consequences in later stages of life in conceived offspring. The present thesis addressed a broad scale of developmental aspects which are important during childhood and adolescence in IVF singletons and spontaneously conceived controls born to subfertile parents. Various cardiovascular measures were examined in view of the “developmental origins of health and disease” hypothesis.

English

DSpace at VU

Growth and Development
of Children 
born after IVF Treatment
Manon Ceelen
G
rowth and D
evelopm
ent of Children born after IV
F Treatm
ent                                                             M
anon C
eelen
During the past decades, in vitro fertilization (IVF) has become 
a routine procedure in reproductive medicine to overcome 
subfertility problems in couples all over the world. Since the 
first IVF birth in 1978, an estimated three million children have 
been born worldwide after IVF or related assisted reproductive 
technologies. Nowadays, there is a substantial body of evidence 
that IVF children are at increased risk for adverse perinatal 
outcome. In addition, various studies suggested an increased 
incidence of congenital abnormalities and rare imprinting diseases 
among IVF children. Nevertheless, several studies indicated that 
IVF children do not differ from spontaneously conceived controls 
in terms of mental and psychomotor development. There is still 
no consensus on whether observed health problems are related 
to the IVF procedure itself, the underlying subfertility problems 
of the parents, or a combination. Due to the lack of systematic 
follow-up of these children during the past years, it is largely 
unclear whether IVF treatment in humans is associated with 
substantial developmental consequences in later stages of life in 
conceived offspring. The present thesis addressed a broad scale 
of developmental aspects which are important during childhood 
and adolescence in IVF singletons and spontaneously conceived 
controls born to subfertile parents. Various cardiovascular 
measures were examined in view of the “developmental origins 
of health and disease” hypothesis.
