Cimanga, Kanyanga

Kambu, K.O.

Makila, B.M.F.

Pieters, Luc

Tona, L.G.

Vlietinck, Arnold

Abstract: Aqueous and 80% methanol extracts from Cryptolepis sanguinolenta root bark and their alkaloids were submitted to an evaluation for their potential amoebicidal activity against Entamoeba histolytica. Results indicated that aqueous and 80% methanol extracts exhibited pronounced amoebicidal activity with minimal amoebicidal concentrations (MAC) of 6.25 and 4.15 \u3bcg/ml respectively and with inhibitory concentrations 50 (IC50) of 4.02 and 2.87 \u3bcg/ml respectively. Among isolated indoloquinoline alkaloids, cryptolepine, the major alkaloid of this plant part and its isomer neocryptolepine showed pronounced amoebicidal activity with MAC values of 3.12 and 1.87 \u3bcg/ml, and IC50 values of 3.27 and 2.07 \u3bcg/ml respectively. Other monomeric alkaloids such as cryptolepine HCl, hydrocryptolepine and quindoline displayed this activity with MAC and IC50 values ranging from 4.25 to 10.68 \u3bcg/ml with quindoline exhibing weak activity (MAC = 10.68 and IC50 =.8.65\ub10.03 \u3bcg/ml. The dimeric alkaloids biscryptolepine and cryptoquindoline also exhibited pronounce

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Assessment of acute and subacute toxicity of aqueous extract and in vitro susceptiblity of extracts and isolated indoloquinoline alkaloids from Cryptolepis sanguinolenta (lindl.) Schlechter (periplocaceae) root bark to Entamoeba histolytica

Assessment of acute and subacute toxicity of aqueous extract and in vitro susceptiblity of extracts and isolated indoloquinoline alkaloids from Cryptolepis sanguinolenta (lindl.) Schlechter (periplocaceae) root bark to Entamoeba histolytica

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Institutional Repository Universiteit Antwerpen