Deleye, Steven

Glassner, Mathias

Hoogenboom, Richard

Monnery, Bryn D.

Palmieri, Luca

Staelens, Steven

Stroobants, Sigrid

Verbrugghen, Thomas

Wyffels, Leonie

Abstract: Poly(2-alkyl-2-oxazoline)s (PAOx) have received increasing interest for biomedical applications. Therefore, it is of fundamental importance to gain an in-depth understanding of the biodistribution profile of PAOx. We report the biodistribution of poly(2-ethyl-2-oxazoline) (PEtOx) with a molar mass of 5 kDa radiolabeled with PET isotopes 89Zr and 18F. 18F-labeled PEtOx is prepared by the strain-promoted azidealkyne cycloaddition (SPAAC) of [18F]fluoroethylazide to bicyclo[6.1.0]non-4-yne (BCN)-functionalized PEtOx as many common labeling strategies were found to be unsuccessful for PEtOx. 89Zr-labeled PEtOx is prepared using desferrioxamine end-groups as a chelator. Five kDa PEtOx shows a significantly faster blood clearance compared to PEtOx of higher molar mass while uptake in the liver is lower, indicating a minor contribution of the liver in excretion of the 5 kDa PEtOx. While [18F]-PEtOx displays a rapid and efficient clearance from the kidneys, 5 kDa [89Zr]-Df-PEtOx is not efficiently cleared over the time course of the study, which is most likely caused by trapping of 89Zr-labeled metabolites in the renal tubules and not the polymer itself, demonstrating the importance of selecting the appropriate label for biodistribution studies

Institutional Repository Universiteit Antwerpen

The label matters : <tex>\mu PET$</tex> imaging of the biodistribution of low molar mass <tex>^{89}Zr$</tex> and <tex>^{18}F$</tex>-labeled poly(2-ethyl-2-oxazoline)

The label matters : <tex>\mu PET $</tex> imaging of the biodistribution of low molar mass <tex>^{89}Zr$ </tex> and <tex>^{18}F$</tex>-labeled poly(2-ethyl-2-oxazoline)

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Institutional Repository Universiteit Antwerpen

The label matters : <tex>\mu PET</tex>imagingofthebiodistributionoflowmolarmass<tex>89Zr</tex> imaging of the biodistribution of low molar mass <tex>^{89}Zr</tex>imagingofthebiodistributionoflowmolarmass<tex>89Zr</tex> and <tex>^{18}F$</tex>-labeled poly(2-ethyl-2-oxazoline)

Abstract

Similar works

Full text

Available Versions

Institutional Repository Universiteit Antwerpen

The label matters : <tex>\mu PET $</tex> imaging of the biodistribution of low molar mass <tex>^{89}Zr$ </tex> and <tex>^{18}F$</tex>-labeled poly(2-ethyl-2-oxazoline)