Objectives: We evaluated whether a oneyear, multifaceted quality improvement intervention improved adherence to 13 clinical guidelines for lipid screening, hypertension management, and diabetes management among White and African-American adult patients. Setting: An academic family medicine center. Participants: Six faculty physicians and a clinical pharmacist participated between July 1, 2002, and June 30, 2003. Data from 2860 patients’ electronic medical records were abstracted. Interventions: Performance reports and lists of patients eligible for each guideline measure were generated. Interventions targeted patients who needed improvement. Statistical analyses used generalized estimating equations to determine the intervention effect. Results: Significant improvements occurred in blood pressure control for all adults (OR51.44) and those with hypertension (OR51.82), measures of total cholesterol (OR51.10) and high-density lipoprotein cholesterol (OR5 1.27) for all patients, and measure of low density lipoprotein cholesterol (OR52.01) and blood pressure control (OR51.71) for patients with diabetes mellitus. Significant decline was seen in measures of blood pressure for all patients (OR5.60). After adjusting for patient demographic factors, provider variability, and comorbidities, race was not associated with the change observed in any of the measures from baseline to follow-up. Conclusions: Even though a multifaceted intervention can improve process of care measures for Whites and African Americans, further studies are needed to improve outcome measures, especially in African Americans