Jalkanen, Aaro

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A b e r c r o m b i e E D , D e B o e r P : S u b s t a n t i a n i g r a D 1 r e c e p t o r s a n d s t i m u l a t i o n o f s t r i a t a l c h o l i n e r g i c interneurons by dopamine: a proposed circuit mechanism.

A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors.

A u d u s K L , N g L , W a n g W , B o r c h a r d t R T : B r a i n m i c r o v e s s e l e n d o t h e l i a l c e l l c u l t u r e s y s t e m s . P h a r m

A: A novel prolyl endopeptidase inhibitor, JTP-4819--its behavioral and neurochemical properties for the treatment of Alzheimer's disease.

A: Lower activity of serum peptidases in abstinent alcohol-dependent patients.

AC: Intracellullar peptides as putative natural regulators of protein interactions.

Acetylcholine and memory: a long, complex and chaotic but still living relationship.

Actions in rodent, primate, and cellular models of antiparkinsonian activity in comparison to ropinirole.

Activation of M1-like muscarinic receptors is required for the induction of corticostriatal LTP.

Activities of dipeptidyl peptidase II, dipeptidyl peptidase IV, prolyl endopeptidase, and collagenase-like peptidase in synovial membrane from patients with rheumatoid arthritis and osteoarthritis.

Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia.

Ahtee L: Effects of ethanol on the accumbal output of dopamine, GABA and glutamate in alcohol-tolerant and alcohol-nontolerant rats.

AJ: A common mechanism of action for three moodstabilizing drugs.

Albini A and Sporn MB: The tumour microenvironment as a target for chemoprevention.

Alpha-synuclein in Lewy bodies.

An inhibitor for post-proline cleaving enzyme; distribution and partial purification from porcine pancreas.

and Armstrong CM: Induction of long-term depression and rebound potentiation by inositol trisphosphate in cerebellar Purkinje neurons.

Angiogenesis in cancer and other diseases.

AP: Epigenetic patterns at the mouse prolyl oligopeptidase gene locus suggest the CpG island in the gene body to be a novel regulator for gene expression.

AP: Localization and subcellular distribution of prolyl oligopeptidase in the mouse placenta.

Attachment, aggression and affiliation: the role of oxytocin in female social behavior.

Auriola S: Quantitative determination of acetylcholine in microdialysis samples using liquid chromatography/atmospheric pressure spray ionization mass spectrometry.

Benowitz LI: Growth-associated protein GAP-43 is expressed selectively in associative regions of the adult human brain.

BJ: Progress in brain penetration evaluation in drug discovery and development.

Blood-brain barrier drug targeting: the future of brain drug development.

Bosmans E, Scharpe S: Lower serum activity of prolyl endopeptidase in anorexia and bulimia nervosa.

Bovine brain microvessel endothelial cell monolayers as a model system for the blood-brain barrier.

BR: Parkinson's disease.

C a v a s i n M A , R h a l e b N E , Y a n g X P , C a r r e t e r o O A : P r o l y l o l i g o p e p t i d a s e i s i n v o l v e d i n r e l e a s e o f t h e antifibrotic peptide Ac-SDKP.

C h a n g Q , C o l o n - R i v e r a C , H a a g R , G o l d P E : A c e t y l c h o l i n e r e l e a s e i n t h e h i p p o c a m p u s a n d striatum during place and response training.

Carretero OA: Ac-SDKP reverses inflammation and fibrosis in rats with heart failure after myocardial infarction.

Carretero OA: Effect of N-acetyl-seryl-aspartyllysyl-proline on DNA and collagen synthesis in rat cardiac fibroblasts.

Carretero OA: Long-term effect of N-acetyl-serylaspartyl-lysyl-proline on left ventricular collagen deposition in rats with 2-kidney, 1-clip hypertension.

Carretero OA: Novel anti-inflammatory mechanisms of N-Acetyl-Ser-Asp-Lys-Pro in hypertension-induced target organ damage.

Casis L: Distribution of prolyl endopeptidase activities in rat and human brain.

Celiac sprue.

Checler F: Influence of region-specific alterations of neuropeptidase content on the catabolic fates of neuropeptides in Alzheimer's disease.

Chronic obstructive pulmonary disease.

Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue.

Concerted structural changes in the peptidase and the propeller domains of prolyl oligopeptidase are required for substrate binding.

Cragg SJ: Striatal muscarinic receptors promote activity dependence of dopamine transmission via distinct receptor subtypes on cholinergic interneurons in ventral versus dorsal striatum.

D e n n y J B : M o l e cu l a r m e c h a n i s m s , b i o l o g i ca l a c t i o n s , a n d n e u r o p h a r m a c o l o g y o f t h e g r o w t h - a s s o c i a t e d protein GAP-43.

D u v o i s i n R C , D i I o r i o G , G o l b e L I , N u s s b a u m R L : M u t a t i o n i n t h e a l p h a - s y n u cl e i n g e n e i d e n t i f i e d i n families with Parkinson's disease.

D: Neuropeptides in learning and memory processes.

D'Ho ndt P , Cosy ns P : Low er seru m proly l endo pe pti dase enzyme activity in major depression: further evidence that peptidases play a role in the pathophysiology of depression.

De nt EW : Tou ch a nd go : guidance cue s signal to the g row th co ne cy toskele to n.

de Yebenes JG: The new mutation, E46K, of alpha-synuclein causes Parkinson and Lewy body dementia.

Degradation of alpha-synuclein by proteasome. J Biol Chem 274: 33855-33858, 1999.61 B e n o w i t z L I , P e r r o n e - B i z z o z e r o N I , F i n k l e s t e i n

Demuth HU: Modulation of inositol 1,4,5-triphosphate concentration by prolyl endopeptidase inhibition.

Depletion of 43-kD growth-associated protein in primary sensory neurons leads to diminished formation and spreading of growth cones.

Distribution of peptidase activity in teleost and rat tissues.

Dive V: RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo66 the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis.

DL: Human alpha-synuclein-harboring familial Parkinson's disease-linked Ala-53 --> Thr mutation causes neurodegenerative disease with alpha-synuclein aggregation in transgenic mice.

E: Alzheimer's disease.

EA: The cholinergic system and neostriatal memory functions.

Effect of barley endoprotease EP-B2 on gluten digestion in the intact rat.

Effect of prolyl endopeptidase inhibition on argininevasopressin and thyrotrophin-releasing hormone catabolism in the rat brain.

Effect of S 17092, a novel prolyl endopeptidase inhibitor, on substance P and alpha-melanocyte-stimulating hormone breakdown in the rat brain.

Effect of the overexpression of wild-type or mutant alpha-synuclein on cell susceptibility to insult.

Effects of diverse psychopharmacological substances on the activity of brain prolyl oligopeptidase.

Effects of memantine on soluble Alphabeta(25-35)-induced changes in peptidergic and glial cells in Alzheimer's disease model rat brain regions.

Effects of the prolyl endopeptidase inhibitor S 17092 on cognitive deficits in chronic low dose MPTP-treated monkeys.

EK: Comparison of proline endopeptidase activity in brain tissue from normal cases and cases with Alzheimer's disease, Lewy body dementia, Parkinson's disease and Huntington's disease.

Evangelatos GP: Effect of thymosin peptides on the chick chorioallantoic membrane angiogenesis model.

Expression and traffic of cellular prolyl oligopeptidase are regulated during cerebellar granule cell differentiation, maturation, and aging.

F e l l n e r L , J e l l i n g e r K A , W e n n i n g G K , S t e f a n o v a N : G l i a l d y s f u n c t i o n i n t h e p a t h o g e n e s i s o f -synucleinopathies: emerging concepts.

F: Circadian rhythms of dopamine, glutamate and GABA in the striatum and nucleus accumbens of the awake rat: modulation by light.

Folkerts G: Cigarette smoke-induced lung emphysema in mice is associated with prolyl endopeptidase, an enzyme involved in collagen breakdown.

Forgez P: NT agonist regulates expression of nuclear high-affinity neurotensin receptors.

Forsberg MM: Comparison of in vitro cell models in predicting in vivo brain entry of drugs.

Fricker LD: Peptidomics of Cpe(fat/fat) mouse brain regions: implications for neuropeptide processing.

Further evidence for a dissociation between different forms of mnemonic expressions in a mouse model of agerelated cognitive decline: effects of tacrine and S 17092, a novel prolyl endopeptidase inhibitor. Learn Mem 7:159-169,

G r a e f S , S c h o n k n e c h t P , S a b r i O , H e g e r l U : C h o l i n e r g i c r e ce p t o r s u b t y p e s a n d t h e i r r o l e i n c o g n i t i o n , emotion, and vigilance control: an overview of preclinical and clinical findings.

Garcia-Horsman JA: Characterization of membrane-bound prolyl endopeptidase from brain.

Garcia-Horsman JA: Combination of snap freezing, differential pH two-dimensional reverse-phase high-performance liquid chromatography, and iTRAQ technology for the peptidomic analysis of the effect of prolyl oligopeptidase inhibition in the rat brain.

Garcia-Horsman JA: Prolyl oligopeptidase is inhibited in relapsing-remitting multiple sclerosis.

GarciaHorsman JA: Prolyl endopeptidase is involved in cellular signalling in human neuroblastoma SH-SY5Y cells.

Giacobini E: Cholinesterase inhibitor effects on extracellular acetylcholine in rat striatum.

Growdon JH: Release of Alzheimer amyloid precursor derivatives stimulated by activation of muscarinic acetylcholine receptors.

H: JTP-4819: a novel prolyl endopeptidase inhibitor with potential as a cognitive enhancer.

Hammarlund-Udenaes M: In vitro methods for estimating unbound drug concentrations in the brain interstitial and intracellular fluids.

HammarlundUdenaes M: Species differences in blood-brain barrier transport of three positron emission tomography radioligands with emphasis on P-glycoprotein transport.

Harwood AJ: Genetic control of lithium sensitivity and regulation of inositol biosynthetic genes. PLoS One 5: e11151,

Harwood AJ: Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate.

HK: Matrigel induces thymosin beta 4 gene in differentiating endothelial cells.

Hong JT: Inflammation and Alzheimer's disease.

HU: Brain prolyl endopeptidase expression in aging, APP transgenic mice and Alzheimer's disease.

I: Flexibility of prolyl oligopeptidase: molecular dynamics and molecular framework analysis of the potential substrate pathways.

Identification and initial characterisation of a N-benzyloxycarbonylprolyl-prolinal (Z-Pro-prolinal)-insensitive 7-(N-benzyloxycarbonyl-glycyl-prolyl-amido)-4-methylcoumarin (Z-Gly-Pro-NH-Mec)-hydrolysing peptidase in bovine serum.

Identification and localisation of a synaptosomal membrane prolyl endopeptidase from bovine brain.

In vivo MR measurements of regional arterial and venous blood volume fractions in intact rat brain.

Increased prolyl endopeptidase activity in human neoplasia.

Inflammation and the degenerative diseases of aging.

Interaction of prolyl oligopeptidase with alpha-synuclein.

Ishitani R: ONO-1603, a potential antidementia drug, delays age-induced apoptosis and suppresses overexpression of glyceraldehyde-3-phosphate dehydrogenase in cultured central nervous system neurons.

Isolation and structural characterization of thymosin-beta 4 from a human medullary thyroid carcinoma.

JE: A dual protease inhibitor/CXCR receptor antagonist with therapeutic implications in chronic inflammatory lung disease. Dissertations in the University of Alabama at

JE: A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation.

JE: A novel proteolytic cascade generates an extracellular matrix-derived chemoattractant in chronic neutrophilic inflammation.

JE: Neutrophils contain prolyl endopeptidase and generate the chemotactic peptide, PGP, from collagen.

The potential of prolyl oligopeptidase as a drug target

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The potential of prolyl oligopeptidase as a drug target

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