Kansanen, Emilia

English

UEF Electronic Publications

2011,&quot;The absence of macrophage Nrf2 promotes atherogenesis in early but not in late stages of atherosclerosis&quot;,

4-Hydroxynonenal-protein adducts: A reliable biomarker of lipid oxidation in liver diseases&quot;,

Accumulation of 15-deoxy-delta(12,14)-prostaglandin J2 adduct formation with Keap1 over time: effects on potency for intracellular antioxidant defence induction&quot;,

Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction&quot;,

Activation of Nrf2 in endothelial cells protects arteries from exhibiting a proinflammatory state&quot;,

Activation of stress singnaling pathways by electrophilic oxidized and nitrated lipids&quot;. Free Radic.Biol.Med.

Activation of vascular endothelial nitric oxide synthase and heme oxygenase-1 expression by electrophilic nitro-fatty acids&quot;,

Alterations in gene expression induced by the lipid peroxidation product, 4-hydroxy-2-nonenal&quot;,

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements&quot;,

Anti-Atherogenic Effect of Laminar Shear Stress via Nrf2 Activation&quot;,

Antiphospholipid antibodies are directed against epitopes of oxidized phospholipids. Recognition of cardiolipin by monoclonal antibodies to epitopes of oxidized low density lipoprotein&quot;,

Atherosclerosis--an inflammatory disease&quot;, N.Engl.J.Med.,

Atherosclerosis. the road ahead&quot;,

Bardoxolone methyl and kidney function in CKD with type 2 diabetes&quot;, N.Engl.J.Med.,

Bioactive products of phospholipid oxidation: isolation, identification, measurement and activities&quot;,

Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products&quot;,

Chemical and molecular regulation of enzymes that detoxify carcinogens&quot;,

Cholesteryl nitrolinoleate, a nitrated lipid present in human blood plasma and lipoproteins&quot;,

Contrasting actions of endothelin ET(A) and ET(B) receptors in cardiovascular disease&quot;,

Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3&quot;,

Covalent peroxisome proliferator-activated receptor gamma adduction by nitro-fatty acids: selective ligand activity and antidiabetic signaling actions&quot;,

Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1&quot;,

Cyclooxygenase-2 generates anti-inflammatory mediators from omega-3 fatty acids&quot;,

Detection and Quantification of Protein Adduction by Electrophilic Fatty Acids: Mitochondrial Generation of Fatty Acid Nitroalkene Derivatives&quot;, Free Radic.Biol.Med.,

Determinants of bioactivity of oxidized phospholipids. Specific oxidized fatty acyl groups at the sn-2 position&quot;,

Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response&quot;,

Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells&quot;,

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants&quot;,

Discovery of the negative regulator of Nrf2, Keap1: a historical overview&quot;,

Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice&quot;, PLoS.One.,

Dissecting the complex physiology of endothelin: new lessons from genetic models&quot;,

Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress&quot;,

Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt&quot;,

Effect of platelet activating factor-acetylhydrolase on the formation and action of minimally oxidized low density lipoprotein&quot;,

Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives&quot;,

Electrophilic fatty acids regulate matrix metalloproteinase activity and expression&quot;,

Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion&quot;,

Endogenous reactive intermediates as modulators of cell signaling and cell death&quot;,

Endothelial dysfunction, hemodynamic forces, and atherogenesis&quot;,

Endothelin system: the double-edged sword in health and disease&quot;,

Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt&quot;,

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide&quot;,

Epoxyisoprostane and epoxycyclopentenone phospholipids regulate monocyte chemotactic protein-1 and interleukin-8 synthesis. Formation of these oxidized phospholipids in response to interleukin-1beta&quot;, J.Biol.Chem.,

Evolving concepts of the role of high-density lipoprotein in protection from atherosclerosis&quot;,

Expression of heme oxygenase-1 in human vascular cells is regulated by peroxisome proliferator-activated receptors&quot;,

Extremely potent triterpenoid inducers of the phase 2 response: correlations of protection against oxidant and inflammatory stress&quot;,

Fatty acid transduction of nitric oxide signaling: multiple nitrated unsaturated fatty acid derivatives exist in human blood and urine and serve as endogenous peroxisome proliferator-activated receptor ligands&quot;,

Fatty acid transduction of nitric oxide signaling: nitrolinoleic acid potently activates endothelial heme oxygenase 1 expression&quot;,

Functional antioxidant responsive elements&quot;,

Generation and biological activities of oxidized phospholipids&quot;,

Heat shock factor 1 attenuates 4-Hydroxynonenal-mediated apoptosis: critical role for heat shock protein 70 induction and stabilization of Bcl-XL&quot;,

Heme oxygenase-1 in cardiovascular diseases: molecular mechanisms and clinical perspectives&quot;,

Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids&quot;,

Identification of protein targets of 4-hydroxynonenal using click chemistry for ex vivo biotinylation of azido and alkynyl derivatives&quot;,

Identification of sensor cysteines in human Keap1 modified by the cancer chemopreventive agent sulforaphane&quot;,

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry&quot;,

Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis&quot;,

Induction of glutathione synthesis by oxidized low-density lipoprotein and 1-palmitoyl-2-arachidonyl phosphatidylcholine: protection against quinone-mediated oxidative stress&quot;,

Induction of heme oxygenase-1 inhibits the monocyte transmigration induced by mildly oxidized LDL&quot;,

Inhibition of Hsp72-mediated protein refolding by 4-hydroxy-2-nonenal&quot;,

Keap1 controls postinduction repression of the Nrf2-mediated antioxidant response by escorting nuclear export of Nrf2&quot;,

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains&quot;,

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex&quot;,

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model&quot;,

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the aminoterminal Neh2 domain&quot;,

Key transcriptional regulators of the vasoprotective effects of shear stress&quot;,

KLF2 primes the antioxidant transcription factor Nrf2 for activation in endothelial cells&quot;,

Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism&quot;,

Lipid peroxidation: physiological levels and dual biological effects&quot;,

Microarray analysis reveals overexpression of CD163 and HO-1 in symptomatic carotid plaques&quot;,

Mitochondrial nitroalkene formation and mild uncoupling in ischaemic preconditioning: implications for cardioprotection&quot;,

Modification of heat shock protein 90 by 4-hydroxynonenal in a rat model of chronic alcoholic liver disease&quot;,

Modification of keap1 cysteine residues by sulforaphane&quot;,

Modifying specific cysteines of the electrophile-sensing human Keap1 protein is insufficient to disrupt binding to the

Modulation of gene expression by cancer chemopreventive dithiolethiones through the Keap1-Nrf2 pathway. Identification of novel gene clusters for cell survival&quot;,

Molecular control of endothelial cell behaviour during blood vessel morphogenesis&quot;,

NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector&quot;,

New drugs for the treatment of diabetes mellitus: part I: Thiazolidinediones and their evolving cardiovascular implications&quot;,

NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection&quot;,

NF-kappaB regulation in the immune system&quot;,

Nitrated fatty acids: Endogenous antiinflammatory signaling mediators&quot;,

Nitric oxide and peroxynitrite in health and disease&quot;,

Nitric oxide in the pathogenesis of vascular disease&quot;,

Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives&quot;,

Nitro-fatty acid formation and signaling&quot;,

Nitro-fatty acid inhibition of neointima formation after endoluminal vessel injury&quot;,

Nitro-fatty Acid Metabolome: Saturation, Desaturation, {beta}-Oxidation, and Protein Adduction&quot;,

Nitro-fatty acid reaction with glutathione and cysteine. Kinetic analysis of thiol alkylation by a Michael addition reaction&quot;,

Nitro-fatty acids and cyclopentenone prostaglandins share strategies to activate the Keap1-Nrf2 system: a study using green fluorescent protein transgenic zebrafish&quot;,

Nitro-fatty acids occur in human plasma in the picomolar range: a targeted nitro-lipidomics GC-MS/MS study&quot;,

Nitro-Fatty Acids Reduce Atherosclerosis in Apolipoprotein E-Deficient Mice&quot;,

Nitro-oleic acid inhibits angiotensin ii-induced hypertension&quot;,

Nitro-oleic acid protects the mouse kidney from ischemia and reperfusion injury&quot;,

Nitro-oleic acid, a novel and irreversible inhibitor of xanthine oxidoreductase&quot;,

Nitrolinoleic acid inhibits vascular smooth muscle cell proliferation via the Keap1/Nrf2 signaling pathway&quot;,

Nitrolinoleic acid: an endogenous peroxisome proliferator-activated receptor gamma ligand&quot;,

Nrf2 gene transfer induces antioxidant enzymes and suppresses smooth muscle cell growth in vitro and reduces oxidative stress in rabbit aorta in vivo&quot;,

Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival&quot;,

Nrf2 is essential for cholesterol crystal-induced inflammasome activation and exacerbation of atherosclerosis&quot;,

Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes&quot;,

Lipid oxidation and nitration products as activators of cytoprotective Nrf2 signaling in the endothelium

http://epublications.uef.fi/pub/urn_isbn_978-952-61-0645-8/urn_isbn_978-952-61-0645-8.pdf

Lipid oxidation and nitration products as activators of cytoprotective Nrf2 signaling in the endothelium

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