Jyrkkänen, Henna-Kaisa

English

UEF Electronic Publications

2011”The absence of macrophage Nrf2 promotes atherogenesis in early but not in late stages of atherosclerosis”,

9, &quot;Regulation of N rf2- de pe nde nt ge ne expre ssio n by 15-deoxy-Delta12,14-prostaglandin J2&quot;,

Ablation of the bach1 gene leads to the suppression of atherosclerosis

Acetylation of Nrf2 by p300/CBP augments promoter-specific DNA binding of Nrf2 during the antioxidant response&quot;, Molecular and cellular biology,

Activation of NAD(P)H:quinone oxidoreductase 1 prevents arterial restenosis by suppressing vascular smooth muscle cell proliferation&quot;,

Activation of Nrf2 by arsenite and monomethylarsonous acid is independent of Keap1-C151: enhanced Keap1-Cul3 interaction&quot;, Toxicology and applied pharmacology,

Activation of stress signaling pathways by electrophilic oxidized and nitrated lipids”, submitted

Amino acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine synthetase&quot;,

An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements&quot;, Biochemical and biophysical research communications,

Anti-Atherogenic Effect of Laminar Shear Stress via Nrf2 Activation&quot;, Antioxidants & redox signaling,

Antioxidant signaling via Nrf2 counteracts lipopolysaccharide-mediated inflammatory responses in foam cell macrophages&quot;,

Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction&quot;,

ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response&quot;,

Atherosclerosis--an inflammatory disease&quot;, The New England journal of medicine,

Atherosclerosis. the road ahead&quot;,

B r y d u n , A . , N a k a n o m e , A . , I t o , S . & I g a r a s h i ,

Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site&quot;, Molecular and cellular biology,

Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants&quot;,

Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells&quot;,

Bach1 inhibits oxidative stress-induced cellular senescence by impeding p53 function on chromatin&quot;,

Bach1 repression of ferritin and thioredoxin reductase1 is heme-sensitive in cells and in vitro and coordinates expression with heme oxygenase1, beta-globin,45 and NADP(H) quinone (oxido) reductase1&quot;,

C h o i , I .

Catalytic and regulatory properties of the heavy subunit of rat kidney gamma-glutamylcysteine synthetase&quot;,

Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway&quot;,

Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products&quot;,

Chau dhu ry , H., Cu hl ma nn,

Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins&quot;, Molecular and cellular biology,

Contribution of NAD(P)H:quinone oxidoreductase 1 to protection against carcinogenesis, and regulation of its gene by the Nrf2 basic-region leucine zipper and the arylhydrocarbon receptor basic helix-loop-helix transcription factors&quot;,

Covalent modification at Cys151 dissociates the electrophile sensor Keap1 from the ubiquitin ligase CUL3&quot;, Chemical research in toxicology,

Crystal structure of the Bach1 BTB domain and its regulation of homodimerization&quot;,

Cul3-mediated Nrf2 ubiquitination and antioxidant response element (ARE) activation are dependent on the partial molar volume at position 151 of Keap1&quot;, The Biochemical journal,

Determinants of bioactivity of oxidized phospholipids. Specific oxidized fatty acyl groups at the sn-2 position&quot;,

Different electrostatic potentials define ETGE and DLG motifs as hinge and latch in oxidative stress response&quot;, Molecular and cellular biology,

Differential responses of the Nrf2-Keap1 system to laminar and oscillatory shear stresses in endothelial cells&quot;,

Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a &quot;tethering&quot; mechanism: a two-site interaction model for the Nrf2-Keap1 complex&quot;,

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants&quot;,

Direct interaction between

Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in mice&quot;,

Disruption of the NAD(P)H:quinone oxidoreductase 1 (NQO1) gene in mice causes myelogenous hyperplasia&quot;,

Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress&quot;, Molecular and cellular biology,

Diverse cardioprotective signaling mechanisms of peroxisome proliferator-activated receptor-gamma ligands, 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone, in reperfusion injury: role of nuclear factor-kappaB, heat shock factor 1, and Akt&quot;,

Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives&quot;,

Electrophilic nitrofatty acids activate NRF2 by a KEAP1 cysteine 151-independent mechanism&quot;,

Endogenous generation and protective effects of nitro-fatty acids in a murine model of focal cardiac ischaemia and reperfusion&quot;,

Endothelial dysfunction, hemodynamic forces, and atherogenesis&quot;,

Endothelial-specific expression of mitochondrial thioredoxin promotes ischemia-mediated arteriogenesis and angiogenesis&quot;,

Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury&quot;,

Expression of glutaredoxin in human coronary arteries: its potential role in antioxidant protection against atherosclerosis&quot;, Arteriosclerosis, Thrombosis, and Vascular Biology,

Free radicals in the physiological control of cell function&quot;,

Functional antioxidant responsive elements&quot;,

Functional polymorphisms in the transcription factor NRF2 in humans increase the risk of acute lung injury&quot;, The FASEB journal : official publication of the Federation of American Societies for Experimental Biology,

Gene expression profile of human endothelial cells over-expressing

Gene therapy: adenovirus vectors&quot;,

Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis&quot;,

Heat shock factor 2 (HSF2) contributes to inducible expression of hsp genes through interplay with HSF1&quot;,

Heat shock factors at a crossroad between stress and development&quot;,

Heat shock factors: integrators of cell stress, development and lifespan&quot;, Nature reviews.Molecular cell biology,

Heat shock provides delayed protection against oxidative injury in cultured human umbilical vein endothelial cells&quot;,

Heat shock response modulators as therapeutic tools for diseases of protein conformation&quot;,

Heme induces ubiquitination and degradation of the transcription factor Bach1&quot;, Molecular and cellular biology,

Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1&quot;, The EMBO journal,

Heme oxygenase 1 determines atherosclerotic lesion progression into a vulnerable plaque&quot;,

Heme oxygenase-1 gene promoter polymorphism is associated with coronary artery disease in Japanese patients with coronary risk factors&quot;, Arteriosclerosis, Thrombosis, and Vascular Biology,

Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1&quot;, Nucleic acids research,

Heme oxygenase-1: unleashing the protective properties of heme&quot;,

Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1&quot;,

Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene&quot;,

High-density lipoprotein modulates oxidized phospholipid signaling in human endothelial cells from proinflammatory to anti-inflammatory&quot;,

Hsp70 promotes TNF-mediated apoptosis by binding IKK gamma and impairing NF-kappa B survival signaling&quot;,

Hsp90 interaction with INrf2(Keap1) mediates stress-induced Nrf2 activation&quot;,

Human glutamate cysteine ligase gene regulation through the electrophile response element&quot;,

Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2&quot;, Circulation research,

Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence&quot;,

Identification of a variant antioxidant response element in the promoter of the human glutamate-cysteine ligase modifier subunit gene. Revision of the ARE consensus sequence&quot;,

Identification of inflammatory gene modules based on variations of human endothelial cell responses to oxidized lipids&quot;,

Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray&quot;,

Identification of polymorphic antioxidant response elements in the human genome&quot;, Human molecular genetics,

Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis&quot;,

Identification of thioredoxin-binding protein-2/vitamin D(3) up-regulated protein 1 as a negative regulator of thioredoxin function and expression&quot;,

Improved synthesis of the epoxy isoprostane phospholipid PEIPC and its reactivity with amines&quot;,

Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways&quot;,

Induction of glutathione synthesis in macrophages by oxidized low-density lipoproteins is mediated by consensus antioxidant response elements&quot;,

Induction of heme oxygenase 1 by moderately oxidized low-density lipoproteins in human vascular smooth muscle cells: role of mitogenactivated protein kinases and Nrf2&quot;, Free radical biology

Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(-/-) knockout mouse. Novel model system for a severely compromised oxidative stress response&quot;,

Intracellular shuttling and mitochondrial function of thioredoxininteracting protein&quot;,

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model&quot;, Molecular and cellular biology,

Keap1 represses nuclear activation of antioxidant responsive elements by

KLF2 primes the antioxidant transcription factor Nrf2 for activation in endothelial cells&quot;,

L a mi na r s he a r s tre ss: me ch a ni s ms by w hi ch e nd o t he l i a l ce l l s t ra ns du ce a n atheroprotective force&quot;,

Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism&quot;,

Lipoprotein clearance mechanisms in LDL receptor-deficient &quot;Apo-B48-only&quot; and &quot;Apo-B100-only&quot; mice&quot;,

Lipoprotein size and susceptibility to atherosclerosis--insights from genetically modified mouse models&quot;,

Low doses of reactive oxygen species protect endothelial cells from apoptosis by increasing thioredoxin-1 expression&quot;,

MafG sumoylation is required for active transcriptional repression&quot;, Molecular and cellular biology,

Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1&quot;, The EMBO journal,

Mechanistic studies of the Nrf2-Keap1 signaling pathway&quot;, Drug metabolism reviews,

microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease&quot;,

MicroRNA-196 represses Bach1 protein and hepatitis C virus gene expression in human hepatoma cells expressing hepatitis C viral proteins&quot;,

MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism&quot;, Breast cancer research and treatment,

Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution&quot;, Genes to cells : devoted to molecular & cellular mechanisms,

Transcription factor Nrf2 mediated gene regulation and signaling in the endothelium

http://epublications.uef.fi/pub/urn_isbn_978-952-61-0582-6/urn_isbn_978-952-61-0582-6.pdf

Transcription factor Nrf2 mediated gene regulation and signaling in the endothelium

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