Transplanting a Bacterial Immune System: Determining the Function of a Novel CRISPR System

Abstract

CRISPR (Clusters of Regularly Interspaced Short Palindromic Repeats) loci and cas (CRISPR-associated) genes provide adaptive immunity (see panel below) in bacteria and have recently been repurposed for genome editing. Systems are structurally and functionally diverse. 2 classes, 6 types, 33 subtypes Very few have been studied experimentally None of the Type IV systems have been characterize

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