Carnell, Susan

D\u27Sa, Viren

Deoni, Sean

Hanratty, Jessica

Klepac-Cera, Vanja J.

LeBourgeois, Monique

McLean, Rebecca

English

ScholarWorks@UMass Amherst

Resilience and Early Brain DevelopmentJessica Hanratty, Viren D’Sa, Sean Deoni, Rebecca McLean, Susan Carnell, Vanja Klepac-Ceraj & Monique LeBourgeoisWhy RESONANCE?! What makes a healthy brain?      From conception and throughout childhood, our brains undergo remarkable change. ! Early development underlies cognition and behavior, is responsive to diverse biological and environmental factors, and may be associated with differences in later outcomes! The goal of RESONANCE is to determine how various factors modulate brain and child development.! Children in foster care and adopted children demonstrate a remarkable degree of resilience.  ! Limited information about the influences of the environment on their growth and neurodevelopmental trajectories.! This study will  1. Characterize trajectories of brain development from early childhood to pre-adolescence;  2. Determine how factors including the benefits of foster care and adoption (diet/nutrition, sleep, activity, etc.), influence cognition and behavior.Growth & Environment! Neurocognition ! Cognitive assessments! Expressive/receptive language! visuospatial/fine motor coordination! attention and executive function! academic learning! social-emotional and behavioral function.! Brain growth! MRI (magnetic resonance imaging) scans! non-sedated conditions (child is asleep or awake, watching a movie)! brain morphology, white matter architecture, microstructure and functional connectivity. ! Environment! child sleep quality,! air quality! nutrition (ASA24) and eating/feeding habits! child physical growth and body composition (PeaPod, BodPod)! directed language (LENA). ! Biological sampling! saliva, stool, urine (microbiome)! shed deciduous teeth (pre- and post-natal heavy metal exposure)What is RESONANCE?! The first longitudinal brain & cognition study following children from early childhood to pre-adolescence.! An extensive suite of neurodevelopment measures to examine functional trends & associations.!  Unique sub-cohorts that     include!Adoptees and foster children (STARK)!Late and moderate pre-term children (PEBBLES)!Full-term children exposed to environmental lead (PUMBA)!Children born small for gestational age or with growth restriction (SIMBA)!Previously enrolled, healthy full-term children (BAMBAM)! Brain development under diverse pre- and post-natal environmental conditions.! Anticipated ~850 children.! Common study design, with visits every 3-6 months until 2.5 years of age, and yearly thereafter.KEY CONTACTSS. Deoni  sdeoni@mac.com V. D’Sa viren_dsa@brown.eduSuccesses & Challenges! Early preliminary findings suggest differential brain development associated with language development, phonological processing, emerging executive function, prematurity, lead exposure, home air quality, and genetic APOE status.! Differences in brain growth are mirrored by differences in cognitive development.Women & Infants Hospital, Warren Alpert Medical School at Brown University, Brown University School of Public Health, Johns Hopkins University School of Medicine, Wellesley College & The University of Colorado at Boulder.Key Findings! Primary successes of RESONANCE to date include: ! The acquisition of more than 2500 fetal, infant, and child MRI and cognitive datasets;! Development of novel functional analysis methods that handle complex data;! Utilization of measures of activity, sleep and air quality to gather data on some environmental influences.! Some of the challenges we anticipate include the identification of individual and cumulative effects of the multitude of factors  that influence child health.   ! This study aims to acquire data on a valuable and often under-studied population of children with a focus on the factors that contribute to the emergence and expression of resilience.KEY WORDSNeurodevelopment, Brain, Infant, Childhood Growth, Myelination, Connectivity, Environmental Influences on BrainFamily Health and SociodemographicsNutrition & Eating BehaviorSleep Oral & Gut MicrobiomeEnvironmental ExposuresFUNDING SOURCESNIH UG3 OD023313, NIH MH087510, Bill & Melinda Gates Foundation OPP151325

RESONANCE: Resilience and Early Brain Development

https://scholarworks.umass.edu/cgi/viewcontent.cgi?article=1266&amp;context=rudd_conf

RESONANCE: Resilience and Early Brain Development

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