The expression of c-myb is strongly associated with the presence of estrogen and progesterone receptors in breast cancer

Abstract

International audienceThe c-myb gene was studied in 112 breast cancers. c-myb and estrogen receptor (ER) transcripts were found in 78 (70%) and 71 (63%) cancers respectively. Of these 71 ER positive cancers, 64 (90%) contained c-myb transcripts and of the 41 ER negative cancers, 27 (66%) did not contain c-myb mRNA. Our data show that c-myb transcripts are strongly associated with ER and progesterone receptors (p less than 10(-4) status in breast cancer. Thus the c-myb expression could be associated with breast cancers of better prognosis and its analysis could allow a better characterization of new subsets of hormono-dependent cancers responding more efficiently to hormonotherapy