La diagnosi sierologica delle gastriti croniche atrofiche

Abstract

The majority of atrophic chronic gastritis is related to the H. pylori infection. Opposite to a small group related with autoimmune diseases. Gastrointestinal endoscopy with biopsies is claimed to be the gold standard for the diagnosis of atrophic gastritis. The morphological abnormalities of gastric mucosa may be associated with changes of gastric secretion. A panel of four serological parameters: serum pepsinogens I and II gastrin-17 and anti-Helicobacter anti-body (GASTROPANEL) is described to be useful to single out gastric atrophic lesions. Additionally, GASTROPANEL can detect the topography of atrophic gastritis (in corpus, in antrum or in both) and the aetiology of atrophic damages. Considering unspecific symptoms on the one hand and the serious sequelae (gastric cancer, anemia, etc...) on the other one of atrophic gastritis, GASTROPANEL could represent a useful tool for the clinical management of patients with upper gastrointestinal symptoms and for selected people at high risk for gastric cancer