The Importance of Platinum Dose Intensity in Treatment of Epithelial Ovarian-Cancer

Abstract

In a retrospective analysis of 294 patients with FIGO stages In and TV epithelial ovarian cancer treated with different polychemotherapy regimens in two prospective randomised phase III trials between 1981 and 1988, we evaluated the importance of platinum dose intensity for survival. The median survival time of 55 patients who were treated without platinum was 11 months, whereas 205 patients who were treated with a polychemotherapeutic regimen with a platinum dose intensity of 8 mg/m(2)/week showed a median survival time of 26 months. Of 34 patients who were treated with a platinum dose intensity of 18 mg/m(2)/week, more than 50% are still alive and therefore the median survival time has not yet been reached (Mantel test