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Pathology Department, New York Medical College

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Touro Scholar Newsletters & Newspapers NYMC Archives Publications Winter 2018 The Path Report Volume 2 Issue 3 Pathology Department, New York Medical College Follow this and additional works at: https://touroscholar.touro.edu/nymc_arch_news  Part of the Higher Education Commons, and the Pathology Commons Recommended Citation Pathology Department, New York Medical College. (2018). The Path Report Volume 2 Issue 3. Retrieved from https://touroscholar.touro.edu/nymc_arch_news/8 This Book is brought to you for free and open access by the NYMC Archives Publications at Touro Scholar. It has been accepted for inclusion in Newsletters & Newspapers by an authorized administrator of Touro Scholar. For more information, please contact daloia@nymc.edu.  Spotlight on Research:   Sudhir Jain, PhD The major objective of my work is to evaluate the contributions of genetic heterogeneity in pathological conditions associated with the cardiovascular-renal systems. In particular, we study single nucleotide polymorphisms in the renin-angiotensin-aldosterone (RAA) axis with an eye towards their impact in the genesis of hypertension; our long term goal being to identify novel molecular targets in this pathway so as to facilitate the development of a "tailored" drug therapy for hypertension and associated pathologies. We have cloned and generated mice models of human angiotensinogen gene and its receptor hAT1R gene variants. We employ these animal models to dissect differential regulation of these target genes whose polymorphisms have been reported in the human population. Apart from blood pressure regulation, we have proposed the use of these animal models, with appropriate modifications, to better understand the role of RAA axis in contributing towards metabolic syndrome and vascular lesions of the brain and the kidneys. We also aim to study the neural regulation of blood pressure by the RAAS in populations demonstrating polymorphic changes in the AGT and AT1R genes.  My recent RO1 proposal (percentile score: 6) titled “Hypertension and inflammation: novel insights from human angiotensin type 1 receptor (hAT1R) variants” is designed to analyze how diet and age affect the cellular gene regulatory networks and alter hAT1R expression using transgenic mouse lines expressing hAT1R variants, Haplotype-I and Haplotype-II. Genetic variations that increase AT1R can cause pathological outcomes associated with renin angiotensin system (RAS) over-activity. We have found that genetic variant Haplotype-I overexpress hAT1R and is associated with hypertension in Caucasians. Since AT1R up-regulation can worsen the pathological outcomes of physiological variables like age and diet, understanding its gene- regulation has high translational value with significant clinical impact. This can function as an “early warning” towards timely and directed therapeutic intervention in patients with Haplotype-I of the AT1R gene.   The Path Report Department Chair J T Fallon, MD, PhD Research Z Darzynkiewicz, MD, PhD N Dimitrova, PhD J Duan, MD H Halicka-Ambroziak, MD, PhD N Haque, PhD W Huang, PhD S Jain, PhD T Kobets, MD, MSPH A Kumar, PhD B Mopidevi, PhD G Williams, MD D Xu, PhD C Yin, MD, MS X Zhou, MD, PhD Clinical P Adem, MD A Arnold, PhD S Barasch, MD A Belmonte, MD L Debelenko, MD, PhD C Gault, MD S Goriah, MD L Han, MD, PhD H Islam, MD, PhD G Kleinman, MD C Kumar, PhD S Narayanan, PhD T Poon, MD J Sandhu, MD F Shakil, MD, PhD G Wang, MD, PhD A Yancoskie, DDS Y Yusuf, MD X Zhang, MD H Zhao, PhD M Zhong, MD, PhD S Zomorrodian, DO Teaching C Carbonaro, PhD P Chander, MD P Lento, MD A Mares, MD F Moy, PhD C Ojaimi, PhD V Richards, MD F H Ronny, MD PhD M Sutton, MD Active Retired I Argani, MD H Godfrey, MD M Iatropoulos, MD, PhD R Zachrau, MD       VOLUME II, ISSUE III WINTER 2019 REDCap Cloud is here!   Contact redcapcloud@nymc.edu with questions.                Contact Us: John T. Fallon III, M.D., Ph.D. Professor and Chairman of Pathology john_fallon@nymc.edu (914) 594-4150 Kathy Woodley Department Administrator kathy_woodley@nymc.edu (914) 594-3084  Department of Pathology—Basic Science Building New York Medical College  Valhalla, NY 10595      REDCap Cloud is here!   Contact redcapcloud@nymc.edu with questions.  Held in the Pathology Conference Room—BSB 414 Every Wednesday at 1:00 pm Date Speaker Affiliation 30-Jan Paul Arnaboldi, PhD Microbiology and Immunology, NYMC 6-Feb Zhaohui Feng, PhD, Rutgers 13-Feb Marcello Cassini, MD, PGY1 Pathology, NYMC 20-Feb Dr. Yibing Qyang, PhD     Yale Univ 27-Feb Sarwat Gilani, MD, PGY3 Pathology, NYMC 6-Mar Dariusz Galkowski, MD, PhD Rutgers 13-Mar Dana Razzano, MD, PGY3 Pathology, NYMC 20-Mar Sudhir Jain, PhD           Pathology, NYMC 27-Mar Shamima Sultana, MD, PGY3 Pathology, NYMC 3-Apr Ximing J Yang, MD, PhD Northwestern Univ 10-Apr Rugved Pattarkine, MD, PGY2 Pathology, NYMC 17-Apr Raj Tiwari, PhD    Interim Chair Microbiology, NYMC 24-Apr Haiyan Li, MD, PGY1 Pathology, NYMC 1-May Rebecca Wilcox, MD Univ Vermont 15-May Austin Guo, PhD Pharmacology, NYMC 22-May Dana Razzano, MD, PGY3 Special Seminar on Global Health Pathology, NYMC 5-Jun Joann Sweasy, PhD Yale 12-Jun Malini Harigopal, MD Title: “Breast Pathology Latest Research” Yale 19-Jun Laura Collins, MD BIDMC 26-Jun Kumarasen Cooper, MBChB, DPhil, FRCPath Title:  “Global Health” UPenn 

The Path Report Volume 2 Issue 3

https://touroscholar.touro.edu/cgi/viewcontent.cgi?article=1007&amp;context=nymc_arch_news

The Path Report Volume 2 Issue 3

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