This study evaluated the impacts of the Sustainable Action against HIV and AIDS in Communities (SAHACOM) Project on health and quality of life of people living with HIV (PLHIV). Outcome indicators from baseline documentation (2010) were compared to those obtained at midterm (2012) and end line (2014). Results showed that HIV prevalence among pregnant women aged 15–24 attending antenatal care decreased from 0.5% at baseline to 0.3% at midterm and end line. Proportion of PLHIV who were on antiretroviral therapy (ART) 12 months after the initiation of the treatment increased from 85% at baseline and midterm to 89.5% at end line. Proportion of PLHIV in need for ART and currently on the treatment increased from 90.0% at baseline to 92.5% at midterm and to 96.0% at end line. Regarding their health status, proportion of PLHIV reporting their overall health as good increased from 52.0% at baseline to 78.3% and 80.2% at midterm and end line, respectively. Similarly, proportion of respondents reporting their overall quality of life as good increased sharply from 35.0% at baseline to 73.3% and 72.0% at midterm and end line, respectively. In conclusion, the SAHACOM is effective in improving health and quality of life of PLHIV in Cambodia
