The study investigated the relation of religious fundamentalism (RF) and prejudice in the presence of two threat conditions: epistemic uncertainty, introduced via threat to beliefs, and existential threat, presented through mortality salience induction. A model of RF as a belief system adopted to manage uncertainty and threat was also presented. Participants were 396 undergraduates, 192 of whom met inclusion requirements. RF was significantly related to prejudice toward women, toward homosexual individuals, and toward other religions, the latter relationship being strongest. No significant effects for threat condition were found. Results indicate that the uncertainty and/or threat introduced by the target groups varied in magnitude and that this uncertainty and/or threat was stronger than that posed by the threat conditions