At this juncture of the United States Space Program a major opportunity exists to give a new impetus to space applications (and space sciences) for the next two decades. It involves a redirection of the U.S. Space Programs from an emphasis of means to one emphasizing scientific and economic application goals of space technology. This opportunity comes about with the successful deployment of the Space Shuttle System in the early 1980s. Four topics are emphasized: 1) The Development of Global Information Systems; 2) Large Space Structures Applications; 3) Space as an Energy Base for Mankind; and 4) Likely Phases of Space Application Development