This paper explores Madeleine Leininger’s Theory of Transcultural Nursing and the importance that her theory has in the realm of modern nursing care. The United States is a nation widely acclaimed for its advances in health care, and nurses hold a vital role in delivering such quality care to their patients, who offer differences in “values, beliefs, and lifeways. In light of the globalization of health care and the stress put on professionalism in nursing, Leininger’s theories and research on comparative human care hold a prominent place in health care that provide congruency in the beliefs and cultural values of the recipient of care. Accordingly, Leininger brings to light “a state of well-being that is culturally defined, valued, and practiced” (Finkelman & Kenner, 2013 p. 70). Leininger’s theory holds true in the clinical setting for the author, as, with regards to Leininger’s stress cultural competence, he remains sensitive to the diversity of cultural needs in the nurse-patient setting