Atrial Fibrillation (AF) is a significant clinical problem and the complications of cardiovascular postoperative AF often lead to longer hospital stays and higher heath care costs. The literature showed that AF may be preceded by changes in electrocardiogram (ECG) characteristics such as premature atrial activity, heart rate variability (HRV), and P-wave morphology. We hypothesize that the limitations of statistics-based attempts to predict AF occurrence may be overcome using a hybrid neuro-fuzzy prediction model that is better capable of uncovering complex, non-linear interactions between ECG parameters. We created a neuro-fuzzy network that was able to classify the patients into the control and AF groups with the performances: 99.42% sensitivity, 99.89% specificity, and 99.74% accuracy for 30 minutes just before AF onset