Dietary consumption of saturated fats and simple sugars exacerbates systolic and diastolic dysfunction and abnormal LV remodeling in diabetic rats

Abstract

The incidence of obesity, type 2 diabetes and cardiovascular disease is increasing in part due to increased consumption of saturated fat and simple sugars. We evaluated the effect of diets high in fat and/or carbohydrate on left ventricular (LV) morphology and function with or without diabetes. Young male rats received control (CON; 12% kcal fat/19% protein/69% carbohydrate), moderate fat and carbohydrate (MFC; 40/15/45%) or high fat (HF; 60/19/21%) diets; LV morphology and function were evaluated at 2 and 14wk. Blood glucose was unchanged at 2wk; however, at 14 wk glucose in MFC was 2-fold higher (