Radiomimetic effects of peroxidizing lipids on nucleic acids and their bases

Abstract

Unoxidized or pre-oxidized methyl lineolate was mixed directly with DNA and purine and pyrimidine bases (1:5 w/w), then incubated at room temperature or at 37/sup 0/C for varying periods of time, at which point samples were analyzed for free radical content by electron spin resonance spectroscopy