Field Application of a Monoclonal Antibody Panel to Differentiate Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Isolates

Abstract

Porcine reproductive and respiratory syndrome (PRRS) is recognized as the most economically devastating disease of swine throughout the world. Nucleotide sequencing and serological studies have deomnstrated sustantial antigenic variation amoung PRRS virus (PRRSV) isolates (Murtaugh, et al., 1995; Nelson, et al., 1993, 1996). Recently, European-like PRRSV isolates have been identified in the US (Rossow, et al. 2000) and other new, highly virulent PRRSV isolates have appeared and affect sows at all stages of gestation causing mortality of adult pigs as well as young pigs (Epperson et al., 1997). Therefore, it is even more important to control the spread of these new strains. Clinical signs vary between herds, indicating that viruses may differ in pathogenicity. Furthermore, effective use of vaccines and management approaches to control PRRS has not always been successful