We report on the high success rates of our new, scalable, computational approach for sign recognition from monocular video, exploiting linguistically annotated ASL datasets with multiple signers. We recognize signs using a hybrid framework combining state-of-the-art learning methods with features based on what is known about the linguistic composition of lexical signs. We model and recognize the sub-components of sign production, with attention to hand shape, orientation, location, motion trajectories, plus non-manual features, and we combine these within a CRF framework. The effect is to make the sign recognition problem robust, scalable, and feasible with relatively smaller datasets than are required for purely data-driven methods. From a 350-sign vocabulary of isolated, citation-form lexical signs from the American Sign Language Lexicon Video Dataset (ASLLVD), including both 1- and 2-handed signs, we achieve a top-1 accuracy of 93.3% and a top-5 accuracy of 97.9%. The high probability with which we can produce 5 sign candidates that contain the correct result opens the door to potential applications, as it is reasonable to provide a sign lookup functionality that offers the user 5 possible signs, in decreasing order of likelihood, with the user then asked to select the desired sign