Sawyer, Colton

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VCU Scholars Compass

Masthead LogoVirginia Commonwealth UniversityVCU Scholars CompassBiology and Medicine Through MathematicsConference 2019May 16th, 10:30 AMA PBPK model of Low-concentration Vitamin DSupplementation in the Absence of SunlightMegan SawyerSouthern New Hampshire University, m.sawyer@snhu.eduFollow this and additional works at: https://scholarscompass.vcu.edu/bammPart of the Medical Pharmacology Commons, Ordinary Differential Equations and AppliedDynamics Commons, and the Physiological Processes CommonsThis Event is brought to you for free and open access by the Dept. of Mathematics and Applied Mathematics at VCU Scholars Compass. It has beenaccepted for inclusion in Biology and Medicine Through Mathematics Conference by an authorized administrator of VCU Scholars Compass. Formore information, please contact libcompass@vcu.edu.https://scholarscompass.vcu.edu/bamm/2019/thur/9Title: A PBPK model of Low-concentration Vitamin D Supplementation in the Absence of Sunlight  Presenter: Dr. Megan Sawyer, Southern New Hampshire University  Abstract: A variety of studies discuss the benefits of vitamin D on human physiology, but few mathematical models explore the response of the human body on low-concentration supplementation of vitamin D under sunlight-restrictive conditions.  Using a physiologically-based pharmacokinetic (PBPK) techniques and published human data, this study developed a model to predict the metabolic cascade of orally derived, low concentration (placebo, 200 IU and 400 IU) supplementation of vitamin D over the course of 28 days in the absence of sunlight.  Adaptations to the standard PBPK model format included a dynamic adipose tissue binding coefficient to compensate for additional lipid and protein binding of vitamin D and its metabolites.   

A PBPK model of Low-concentration Vitamin D Supplementation in the Absence of Sunlight

https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1289&amp;context=bamm

A PBPK model of Low-concentration Vitamin D Supplementation in the Absence of Sunlight

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