Ciupe, Stanca

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Masthead LogoVirginia Commonwealth UniversityVCU Scholars CompassBiology and Medicine Through MathematicsConference 2019May 16th, 11:30 AMEarly events during hepatitis B virus infectionsStanca Ciupestanca@vt.eduFollow this and additional works at: https://scholarscompass.vcu.edu/bammPart of the Life Sciences Commons, Medicine and Health Sciences Commons, and the PhysicalSciences and Mathematics CommonsThis Event is brought to you for free and open access by the Dept. of Mathematics and Applied Mathematics at VCU Scholars Compass. It has beenaccepted for inclusion in Biology and Medicine Through Mathematics Conference by an authorized administrator of VCU Scholars Compass. Formore information, please contact libcompass@vcu.edu.https://scholarscompass.vcu.edu/bamm/2019/thur/22Abstract. Experimental studies in non-human primates inoculated with hepatitis B virus have shown that virus dose influences the kinetics of virus spread and the disease outcome. In particular, high and low doses lead to 100% liver infection, while intermediate doses lead to less than 0.1% liver infection. To determine the relationship between virus dynamics, percentage of liver infection, and immune priming we developed an in-host mathematical model that considers the effects of cellular immune responses in controlling the disease. We fitted the model to data and predicted correlations between dose size, the timing of the immune response, the potency of immune effects, and disease outcome. Such results can guide our understanding of the virus-host dynamics that control the virus or permit a transition to chronic disease.  Authors  • Stanca Ciupe, Virginia Tech, U.S., stanca@vt.edu • Jonathan Forde, Hobart and William Smith Colleges, U.S., forde@hws.edu • Naveen K. Vaidya, San Diego State University, U.S., nvaidya@sdsu.edu  

Early events during hepatitis B virus infections

https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1297&amp;context=bamm

Early events during hepatitis B virus infections

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