Cherry, Elizabeth M.

Fenton, Flavio H.

Ji, Yanyan Claire

Kaboudian, Abouzar

English

VCU Scholars Compass

Virginia Commonwealth UniversityVCU Scholars CompassBiology and Medicine Through MathematicsConference 2018May 30th, 4:00 PM - 4:30 PMStudy of Early After Depolarization in a ComplexHuman Cardiac Cell Model in TissueAbouzar KaboudianGeorgia Institute of Technology, abouzar.kaboudian@physics.gatech.eduYanyan Claire JiGeorgia Institute of Technology, yji47@gatech.eduElizabeth M. CherryRochester Institute of TechnologySee next page for additional authorsFollow this and additional works at: https://scholarscompass.vcu.edu/bammPart of the Cardiology Commons, Cardiovascular Diseases Commons, Life Sciences Commons,and the Physical Sciences and Mathematics CommonsThis Event is brought to you for free and open access by the Dept. of Mathematics and Applied Mathematics at VCU Scholars Compass. It has beenaccepted for inclusion in Biology and Medicine Through Mathematics Conference by an authorized administrator of VCU Scholars Compass. Formore information, please contact libcompass@vcu.edu.https://scholarscompass.vcu.edu/bamm/2018/wednesday/11Presenter InformationAbouzar Kaboudian, Yanyan Claire Ji, Elizabeth M. Cherry, and Flavio H. FentonThis event is available at VCU Scholars Compass: https://scholarscompass.vcu.edu/bamm/2018/wednesday/11Study of Early After Depolarization in a Complex Human Cardiac Cell Model in Tissue   Abouzar Kaboudian, Yanyan Claire Ji, Elizabeth M. Cherry, Flavio H. Fenton  Abstract Early After Depolarization (EAD) activations are considered one of the mechanisms in which some of the most dangerous arrhythmias are initiated in the heart. Experimentally, some drugs have been shown to induce EADs. However, little is known about how they initiate and specially how they propagate in tissue.  In this study, we use one of the most updated cardiac ionic models, namely O’Hara-Ruddy model, which consist of over 35 nonlinear ordinary differential equations per cardiac cell to investigate the initiation of EADs as a function variability in the ionic channels dynamics from single cell to tissue. To be able to study this cardiac model in space, we use our in-house developed WebGL library to accelerate simulations with Graphical Processing Units (GPU). We show how coupling effects in space can change the behavior of EADs, spiral waves, and complex spatio-temporal patterns resembling fibrillation.  

Study of Early After Depolarization in a Complex Human Cardiac Cell Model in Tissue

https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1254&context=bamm

Study of Early After Depolarization in a Complex Human Cardiac Cell Model in Tissue

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