Lerma, Claudia

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VCU Scholars Compass

Masthead LogoVirginia Commonwealth UniversityVCU Scholars CompassBiology and Medicine Through MathematicsConference 2019May 16th, 9:00 AM - 10:00 AMPlenary Talk: Nonlinear dynamics ofcardiovascular control in end-stage renal diseasepatientsClaudia LermaInstituto Nacional de Cardiología, Ignacio ChávezFollow this and additional works at: https://scholarscompass.vcu.edu/bammPart of the Life Sciences Commons, Medicine and Health Sciences Commons, and the PhysicalSciences and Mathematics CommonsThis Event is brought to you for free and open access by the Dept. of Mathematics and Applied Mathematics at VCU Scholars Compass. It has beenaccepted for inclusion in Biology and Medicine Through Mathematics Conference by an authorized administrator of VCU Scholars Compass. Formore information, please contact libcompass@vcu.edu.https://scholarscompass.vcu.edu/bamm/2019/thur/20Patients with end-stage renal disease (ESRD) on long-term dialysis therapy die predominantly due to cardiovascular causes. Many risk factors for arrhythmias and sudden cardiac death in these patients are related to cardiovascular control adaptations, as a consequence of chronic hyperactivity of their sympathetic nervous system. We have studied such cardiovascular adaptations through time series analysis of heart rate variability (HRV) and a mathematical model. HRV analysis with different linear and nonlinear methods show that although sympathetic predominance affects the dynamical HRV behavior, these patients have a preserved capacity of response to cardiovascular stimuli such as active standing and hemodialysis. Numerical simulations in a mathematical model of short-term cardiovascular control showed that cardiovascular stability in ESRD requires specific adaptations associated with sympathetic hyperactivity (increased arterial stiffness, faster heart rate, and longer baroreflex delay). We will discuss how these adaptations help to preserve hemodynamic stability, but by inducing less variability to the cardiovascular system, such stability is more fragile in ESRD patients compared to healthy subjects.  

Plenary Talk: Nonlinear dynamics of cardiovascular control in end-stage renal disease patients

https://scholarscompass.vcu.edu/cgi/viewcontent.cgi?article=1362&context=bamm

Plenary Talk: Nonlinear dynamics of cardiovascular control in end-stage renal disease patients

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