Salicylates have been shown to increase the serum creatinine and decrease the creatinine clearance in normal volunteers and patients with rheumatoid arthritis and systemic lupus erythmatosus. Our clinical impression is that patients on long term salicylate therapy do not have creatinine clearances or serum creatinines which differ from the norm. We decided to study the effect of a five-week period of salicylate therapy on the creatinine clearance and serum creatinine of normal volunteers
