Abstract: The purpose of this retrospective case report is to describe the usefulness of a comprehensive assessment of the musculoskeletal and neurological systems and treatment of components of the kinetic chain in a teenage athlete with chronic lateral knee pain. Method: This is a retrospective case report. Discussion: Significant qualities of this case include identification of possible tibiofibular dislocation, optimization of lower extremity (LE) alignment, use of foot orthoses during phases of recovery and utilization of the Knee injury and Osteoarthritis Outcome Score (KOOS) during this cycle of care. Conclusion: When treating a patient with lateral knee pain, full consideration of alignment, fibular position and stability, proprioception, balance, strength and motor control of hip, knee, ankle and foot as well as the contralateral LE and trunk should be considered as influential factors that may need to be addressed