This work was supported by National Science Foundation Grant PHY 76-84033 and Indiana Universit

Blue, J.

Friesel, D.L.

Smith, W.

Wellman, H.N.

English

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PRODUCTION OF HIGH-PURITY 1231 FOR CLINICAL AND RESEARCH PURPOSES 
D.L.  F r i e s e l ,  J. ~ l u e  ,* H.N. wellman: and W. Smith 
The motivation f o r  t he  production of high temperature w i l l  cause t h e  Iodine  t o  condense out  
p u r i t y  1 2 3 ~  stems from its use i n  nuclear  medicine. of t h e  t a r g e t  a r ea ,  causing blockage of t h e  helium 
The advantages of  i ts use compared t o  o the r  radio- gas l i n e s ,  and eventua l ly  having no ma te r i a l  i n  
i so topes  have been thoroughly reviewed1 s 2  s 3  a long the  t a r g e t  a rea .  The d i f f i c u l t y  a r i s e s  because 
wi th  t h e  var ious  means of i ts production.  y 5  s 6  The the  temperature d i f f e r ence  between these  extremes 
'' is q u i t e  small (< 10°C). Beam i n t e n s i t i e s  on t a r -  program a t  Indiana u t i l i z e s  t h e  1 2 7 ~ ( p  ,5n) 1 2 3 ~ e  + 
1 2 3 ~  r eac t ion  on a pure 1 2 7 ~  "Self-Vapor Cooled" ge t  vary considerably from run t o  run and during 
t a r g e t  system of t h e  type described by Blue e t  a 1  . any given 6 hour i r r a d i a t i o n .  Hence, a thermis tor  
A complete desc r ip t ion  of t he  t a r g e t  and c o l l e c t i o n  cont ro l led  temperature r egu la t ion  u n i t  is being 
system can be found i n  l a s t  yea r ' s  Technical Report. i n s t a l l e d  on t h e  Present  t a r g e t  t o  i n su re  a con- 
The development e f f o r t  on t h e  t a r g e t  system s t a n t  temperature during i r r a d i a t i o n .  
was mainly aimed a t  improving the  r e l i a b i l i t y  and Another improvement was made i n  t h e  i so tope  
r e u s a b i l i t y  of t h e  1 2 7 ~  t a r g e t ,  which has a demon- production room wi th  t h e  i n s t a l l a t i o n  of a mult i-  
s t r a t e d  a b i l i t y  of producing I% a t  a r a t e  of 16 pos i t i on  f o i l  changing system i n  t h e  beam l i n e  
mCi/pAhr. A recent  s tudy by Paans e t  a1.8 has re-  upstream of t h e  1 2 7 ~  t a r g e t .  The system cons i s t s  
measured t h e  127~(p ,5n )  1 2 3 ~ e  r e a c t i o n  c ros s  s ec t ion  of two wheels of  9 pos i t i ons  each. Carbon f o i l s  
and est imated t h e  maximum y i e l d  of 1 2 3 ~  from t h i s  of var ious  th icknesses  ranging from 4 t o  26 mm a r e  
r eac t ion  t o  be approximately 21 m~i /pAhr .  Our loca ted  i n  t h e  t a r g e t  wheels t o  f a c i l i t a t e  energy 
measured r a t e  is t h e  amount removed from t h e  t r a p ,  v a r i a t i o n s  of t h e  beam on t a r g e t .  The optimum pro- 
hence, t he  d i f f e r ence  is be l ieved t o  be caused by ton  beam energy on t h e  1 2 7 ~  t a r g e t  f o r  1 2 3 ~  produc- 
no t  completely removing a l l  of t h e  1 2 3 ~  from t h e  t i o n  is 100 MeV. The use of t h i s  energy degrading 
t r a p ,  a s  we l l  a s  not  co l l ec t ing  a l l  t he  1 2 3 ~ e  pro- system, however, w i l l  al low the  use of any proton 
duced i n  t h e  t a r g e t .  beam energy from 80 t o  180 MeV f o r  i so tope  produc- 
The p r i n c i p l e  requirement of t he  t a r g e t  as- t i o n  without  r equ i r ing  a cyclo t ron  energy change. 
sembly f o r  proper opera t ion  is t o  keep t h e  tempera- Comparisons a r e  cu r r en t ly  being made between 
t u r e  of t h e  1 2 7 ~  cons tant  throughout bombardment. t h i s  t a r g e t  system and t h e  133~s self-vapor cooled 
I f  t h e  temperature is too low, such t h a t  t h e  Iodine t a r g e t g  ( a l s o  described i n  t h i s  repor t )  f o r  t he  
is not  i n  l i q u i d  form, t h e  1 2 3 ~ e  produced does n o t  production of  1 2 3 ~ .  The advantages of t h e  133~s 
r e a d i l y  escape t h e  t a r g e t  ma te r i a l  t o  be co l l ec t ed  t a r g e t  a r e  t h a t  it does no t  have t h e  s t r i n g e n t  
i n  t h e  cold  t r ap .  On t he  o the r  hand, a too  high opera t ing  temperature requirements of t h e  1 2 7 ~  
target, and it can also be used to produce other 
radioxenon isotopes simply by changing the inci- 
dent beam's energy. Its disadvantages are a re- 
duced production rate and a higher level of 
contamination by neighboring radioiodines. Work 
is continuing on the 133~s target to determine 
the production rate and purity for 123~. 
%ASA-L~W~S Research Center, Cleveland, Ohio 44 135 
Indiana University Medical Center, Indianapolis, 
IN 46202 
1) W. Meyers, Radioactive Pharmaceuticals, Proc. 
ORINS Symposium, Nov. 1965 (USAEC, Div. Tech. 
Inf., 1966), page 217. 
2) H.N. Wellman et al., CRC Critical Reviews in 
Clinical Radiology and Nuclear Medicine, p. 
81 (Feb. 1975). 
3) Proc. Symposium on Applications of 123~ in 
Nuclear Medicine (Bureau of Radiological 
Health, Rockville, Md., 1975). 
4) V.J. Sodd et al., Tech. Report BRH/DMRE 70-4 
(Bureau of Radiological Health, Rockville, 
Md., 1970). 
5) V.J. Sodd, Intern. Symp. on Radio Pharma- 
ceuticals, Feb. 12-15, 1974. 
6) M.A. Fusa et al., Journal of Nuclear Medicine 
14, 729 (1972). 
-
7) J.W. Blue et al., NASA Tech. Mem., NASA TMX- 
71620, Oct. 1974. 
8) A.M.J. Paans et al., Int. Journal of Applied 
Radiation and Isotopes, Vol. 27, No. 8, 465 
(1976). 
9) D.L. Friesel et al., A Study of Radioxenon 
Production from Proton Bombardment of Metalic 
Cesium, This Report, p. 153. 


Production of High-Purity 123-I for Clinical and Research Purposes

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Production of High-Purity 123-I for Clinical and Research Purposes

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