The Effect of Vitamin D Supplementation on Anthropometric Indices and Total Testosterone in Women with Polycystic Ovary Syndrome Treated with Low Calorie Diet: A Randomized Clinical Trial

Abstract

Background and Objectives: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age women. In the present study, the effect of weight loss diet and vitamin D supplementation was investigated on total testosterone, anthropometric indices, and body composition in patients PCOS.   Methods: In this controlled clinical trial, 60 PCOS women with vitamin D deficiency, were randomly received vitamin D3 supplementation orally at the dose of 50000IU/week along with weight-loss intervention or one placebo/week along with weight-loss diet for 12 weeks. At the beginning and the end of the study, indices, such as anthropometric, body composition, serum level of 25-hydroxyvitamin D3, and total testosterone, were measured using parametric and non-parametric tests.   Results: After a 12-week intervention, the median of serum 25-hydroxyvitamin D3 significantly increased from 18.5 to 42.69ng/ml in vitamin D group compared to the placebo group (p<0.001). Moreover, the mean of weight, body mass index (BMI), Waist circumference, hip circumference, waist to hip ratio, and fat mass significantly decreased in both groups, but was not different between the two groups. The mean of total testosterone decreased from 0.7 to 0.5ng/ml in vitamin D group, which was not statistically significant.   Conclusion: According to the results of this study, vitamin D supplementation in combination with low-calorie diet had no effect on total testosterone