In this study, an ex vitro digestion system was used to simulate the digestion of the whole plant Artemisia annua to gain insight into how artemisinin, the key drug component in malaria treatment, and synergistic flavonoids become bioavailable during digestion. Various delivery methods and staple foods were combined with the plant material for digestion. This study found that sucrose, canola oil, and white rice did not reduce the amount of artemisinin released in the intestinal liquid fraction while vegetarian and gelatin capsules showed a significant reduction in artemisinin release. The sucrose and canola oil A. annua delivery methods also exhibited significantly high flavonoid release. High artemisinin and flavonoid content in the intestinal liquid fraction indicates bioavailability
