The concentrations of serotonin in various brain areas were significantly decreased in
the pyridoxine-deficient young rat.
2. There was no change in the concentration of dopamine.
3. Both Bmax and Kid of [3H]serotonin binding to membrane preparations from cerebral cortex
were increased in deficiency and were restored to normal upon pyridoxine supplementation.
4. There was no change in [3H]spiroperidol binding to corpus striatal membrane preparations
in pyridoxine-deficient rats
