Tissue biomarkers detected by immunohistochemistry as diagnostic and prognostic indicators in human malignancies

Abstract

Immunohistochemistry involves the use of labelled antobodies to detect and visualise the presence of selected antigens. It is widely used in the doagnosis of cancers in which specific antigens are either up-regulated or absent.«br /» We are studying newly-discovered biomarkers such as BAP1, and are suggesting novel uses for them in the diagnosis of cancers such as malignant mesothelioma, cholangiocarcinoma, and gynecological malignancies.«br /» We are also examining the role of microsatellite instability in the diagnosis of colorectal cancer and adrenocortical cancer