Synthesis of Some Carhamates of Steroidal Lactams and Lactones as Possible Alkylating Agents

Abstract

16-0xo-l 7 a-aza-5o.-androstan-3-yl N-alkyl/phenylcarbamates (I-V), 16-oxo-l 7a-oxa-5a-androstan-3-yl N-ethylcarbamate (VI), 16-oxo-l 7a-aza-5-androsten-3-yl N-alkyl/phenylcarbamates (VII-:IX) and 4-oxo-3-aza-A-homo-4a-androsten-l 7B-yl N-phenylcarbamate (X) were prepared by the action of substituted isocyanate on the corresponding steroidal lactams or lactone