The Synthesis and Structure Determination of Tetrasubstituted 4,4\u27 -Biisoxazoles

Abstract

Tetrasubstituted 4,4\u27-biisoxazoles were synthesized as a mixture of isomers by treatment of enolic tautomers of 3,4-diaroyl-2,5-hexanedione with hydroxylamine hydrochloride. A single isomer,· 3,3\u27- diphenyl-5,5\u27-dimethyl-4,4\u27-biisoxazole was isolated from the reaction product mixture. The structure of these compounds has been determined by spectrometric measurements (ir, 1H NMR and mass spectra). Mass spectra have been studied in detail. The determination of metastable transitions and accurate masses of important fragment ions led to the construction of fragmentation schemes

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