Neuroimaging in brain development malformations EUROIMAGING IN BRAIN DEVELOPMENT MALFORMATIONS

Abstract

Prikazani su rezultati studije ocjene vrijednosti ultrazvuka, kompjutorizirane tomografije i magnetne rezonancije u dijagostificiranju poremećaja prouzročenih anomalijama u razvoju mozga. Studijom je obuhvaćeno 70 djece s cerebralnim anomalijama dijagnosticiranim primjenom UZV, CT i MR u razdoblju od 1984. do 1995. godine, koja su klinički obrađivana u Klinici za dječje bolesti Zagreb. U radu je primijenjena modificirana klasifikacija anomalija mozga prema De Myeru. Navedena klasifikacija polazi od stupnja razvoja u kojem anomalija nastaje, pa govorimo o cerebralnim anomalijama uslijed poremećaja citogeneze, histiogeneze ili organogeneze. UZV je osnovna metoda u dijagnostici intrakranijskih anomalija i mora biti primijenjen kao "screening" metoda. S obzirom da značajan broj anomalija mozga može ostati neprepoznat ukoliko se primjenjuje samo UZV, potrebno je, ponekad, primijeniti i CT ili MR, a pogotovo nakon zatvaranja fontanele djeteta. Primjenom kombinacije radioloških metoda uz kliničke i laboratorijske nalaze, u mogućnosti smo utvrditi konačnu dijagnozu anomalija mozga u velikom broju djece, a što je vrlo značajno s kliničkog, prognostičkog i genetskog stajališta.The paper presents the results of the study of the value of ultrasound (US), computed tomography (CT) and magnetic resonance (MR) in the diagnostics of brain development malformations, In the period from 1984 to 1995 US, CT and MR examinations were performed on 70 children with cerebral development malformations who were treated at the Children\u27s Hospital in Zagreb. In our study we applied the classification of cerebral malformations by De Myer. This Classification is based on the stage in the foetal development in which malformation occurs: disorders of cytogenesis, disorders of histogenesis or organogenesis. US is the basic imaging method in the diagnostics of cerebral malformations and must be used as a screening method. However, CT and MR, have to be used sometimes especially after the closure of a child\u27s fontanelle, because some of the malformations can be misdiagnosed if US is applied alone. The combination of imaging methods, clinical and laboratory findings enables us to set the definite diagnosis in children with cerebral malformations. This is very important from clinical, genetic and prognostic points of view

    Similar works