Perioperative blood transfusion as a possible prognostic factor in laryngeal cancer

Abstract

Retrospektivno je istraživan značaj perioperativne transfuzije krvi na tijek i ishod bolesti u 116 bolesnika koji su zbog raka grkljana operirani u Klinici za bolesti uha, nosa, grla i cervikofacijalnu kirurgiju Kliničkog bolničkog centra u Zagrebu u razdoblju od 1985. do 1990. godine. U istraživanu skupinu uključeni su bolesnici s karcinomima II. do IV. stupnja bolesti, jer među bolesnicima I. stupnja karcinomske bolesti nije zapažen ni jedan recidiv, niti je u bilo kojeg bolesnika tog stupnja primijenjena transfuzija krvi. Recidiv je zapažen u 73 bolesnika (62,9%), i to: u 42 (70%) od 60 bolesnika koji su perioperativno primili transfuziju krvi; te u 31 (55,4%) od 56 bolesnika koji nisu primili transfuziju krvi. Uočena razlika nije statistički značajna. U prvoj godini praćenja registrirano je u skupini osoba koje su perioperativno dobile transfuziju krvi 33 (45,2%) recidiva od 73 recidiva zapažena u obje skupine (ili 78,6% od 42 osobe koje su perioperativno primile transfuziju krvi te dobile recidiv u cijelom trogodišnjem razdoblju praćenja; preostalih 9 recidiva zapaženo je u drugoj godini praćenja). U skupini osoba koje nisu primile transfuziju krvi, recidivi su raspodijeljeni tako da je 15 recidiva zapaženo u prvoj godini, te 16 u drugoj i trećoj godini praćenja. U skupini osoba koje su primile transfuziju krvi statistički je značajno zapažanje ranije pojave recidiva (x2 12,379; DF2;P<0.001).A retrospective study was conducted on the influence of perioperative blood transfusion on the course and outcome of the disease with 116 patients on whom a surgical proce­dure had been performed at the ENT department, Zagreb University Hospital, in the period from 1985 to 1990. The group under research in cluded only the patients with laryngeal cancer in the 2nd do 4th stage, be cause patients in the 1st stage of the disease had neither received blood transfusion nor had a recurrence. Recurrence, however, was noted in 73 (62.9 %) patients i.e. in 42 (70 %) patients who received blood transfusion perioperatively and in 31 (55.4 %) patients who did not received blood transfusion. The difference was not statistically significant. During the first post-operative year 73 recurrences occurred, 33 (45.2%) of which in the group that received perioperative blood transfusion (i.e., 78.6% of the 42 persons who received perioperative blood transfusion and had a recurrence in the three-year observation period; the remaining 9 recurrences occurred during the 2nd year of the observation), and 16 during the remaining two years of the observation. Earlier recurrences in the patients who received perioperative blood transfusion are statistically significant (x2 12.379; DF 2; P<0.001)