Scientific Unit for Clinical and Medical Research, Osijek University Hospital
Abstract
Istraženi su nanokompleksi anionskoga biopolimera, karagena i kationske površinski aktivne tvari za primjenu u terapijskim sustavima. Struktura i veličina kompleksa od nano- do mikrodimenzija ovise o koncentraciji i omjeru koncentracija pojedinih komponenata, te linearnoj gustoći naboja na lancu karagena. Faktori o kojima ovisi kompleksiranje jesu elektrostatska i hidrofobna međudjelovanja, te konformacija karagena. Porastom koncentracije karagena, unutar-makromolekulski kompleksi prelaze u među-makromolekulske, koji se postupno reorganiziraju u uređenije strukture, divovske vezikule, talog - dodecilamonijev karagenat i gel. Nastajanje divovskih vezikula i strukturna svojstva netopljivih kompleksa i urušenoga gela pokazuju daje lamelno uređenje stuktuma značajka kompleksa karagena i kationske površinski akivne tvari.Nanocomplexes formed from anionic biopolymers, carrageenans, and cationic surfactant have been investigated for their applicability in drug delivery. Stucture and complex size from nano- to microdimension strongly depends on concentration and concentration ratio of both components and linear charge density on carrageenan chains. Factors governing the complex formation are electrostatic and hydrophobic interactions as well as conformation of the carrageenan chains. With increasing carrageenan concentration, the intra-macromolecular complexes change to inter-macromolecular, which subsequently reorganize into bettei ordered structures, giant vesicles, precipitate - dodecylammonium carrageenate and gels. Formation of giant vesicles and structural properties of insoluble complexes and collapsed gels revealed lamellar ordering as an important feature of the carrageenan and an oppositely charged surfactant complexes
