Abdulkadir, Ahmed

Grothe, Michel

Kaller, Christoph P.

Klink, Katharina

Klöppel, Stefan

Lahr, Jacob

Minkova, Lora

Peter, Jessica

Schumacher, Lena V.

Teipel, Stefan

Bern Open Repository and Information System (BORIS)

The goal of this study was to predict episodic memory change with several markers of neurodegenerative processes in patients with mildcognitive impairment (MCI). Cross sectional studies have shown that degeneration of the basal forebrain cholinergic system (BFCS) isassociated with cognitive decline in MCI1. Longitudinally, atrophy rates in the BFCS - but not in the hippocampus – were predictive of generalcognitive decline in a sample of healthy elderly participants and patients with mild AD2.We obtained baseline and follow-up data in healthy elderlyparticipants as well as in patients with MCI within a time interval of1.5 years (range: 15-18 months). We extracted grey mattervolumes of the BFCS (CH 1- 4) and automatically processed MRIdata with the FreeSurfer longitudinal stream (version 6.0.0)3. Forthe evaluation of verbal episodic memory, we repeatedly assessedthe delayed free recall by using the verbal learning and memorytest (VLMT)4.IntroductionParticipantsResultsPredicting verbal episodic memory changes with longitudinal measures of brain atrophy in mild cognitive impairmentKatharina Klink1, Ahmed Abdulkadir1,2, Lora Minkova1,3, Michel Grothe4, Stefan Teipel4, Lena V. Schumacher5, Christoph P. Kaller6, Jacob Lahr3,   Stefan Klöppel1 , Jessica Peter11 University Hospital of Old Age Psychiatry and Psychotherapy, University of Bern, Switzerland2 Department of Computer Science, University of Freiburg, Germany3 Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Freiburg, Germany4 German Centre for Neurodegeneration Diseases (DZNE), Rostock/Greifswald, Germany5 Medical Psychology and Medical Sociology, Faculty of Medicine, University of Freiburg, Germany6 Freiburg Brain Imaging, Department of Neurology, Faculty of Medicine, University of Freiburg, GermanyContact:Katharina KlinkUniversity Hospital of Old Age Psychiatry and PsychotherapyUniversity of BernE-Mail: katharina.klink@upd.unibe.chWeb: http://www.app.unibe.ch/Following up the presented analysis, we will use a logisticregression approach to classify participants according to theiratrophy in the BFCS and the hippocampus (both cross-sectionaland longitudinal). This will allow us to further our understanding ofbrain changes in MCI and their impact on cognitive functioning.We used a linear mixed model, which allows to include drop-outs’ baseline data. A significant main effect of change in hippocampal volume(F(1, 96.91) = 7.52, p = 0.007) indicated a relationship with changes in verbal delayed recall performance for patients with MCI compared tohealthy controls. BFCS volume changes (F(1, 91.98) = 0.3, p = 0.59) did not show this association. Mean outcome values of the includedvariables are shown in Fig. 1.DescriptivesVisit Group n Age Education MoCA Gender 1 HC 37 69.6 (5.7) 14.9 (3.3) 27 (1.9) 13 m/ 24 fMCI 31 73.9 (5) 13.2 (3.3) 22.3 (3.2) 14 m/ 17 f2 HC 23 71.4 (5.6) 14.8 (3.4) 26.3 (2.5) 14 m/ 9 fMCI 15 76.1 (4) 13.6 (3.2) 20.3 (4.3) 7 m/ 8 fNote. HC, healthy controls; MCI, mild cognitive impairment; MoCA, Montreal Cognitive Assessment; mean (standard deviation)1.Grothe, M. J., Heinsen, H., Amaro, E., Grinberg, L. T. & Teipel, S. J. Cognitive Correlates of Basal Forebrain Atrophy and Associated Cortical Hypometabolism in MildCognitive Impairment. Cereb. Cortex 26, 2411–2426 (2016).2.Grothe, M., Heinsen, H. & Teipel, S. Longitudinal measures of cholinergic forebrain atrophy in the transition from healthy aging to Alzheimer’s disease. Neurobiol. Aging34, 1210–1220 (2013).3.Reuter, M., Schmansky, N. J., Rosas, H. D. & Fischl, B. Within-subject template estimation for unbiased longitudinal image analysis. Neuroimage 61, 1402–1418 (2012).4.Helmstaedter, C., Lendt, M. & Lux, S. Verbaler Lern- und Merkfähigkeitstest. (2001).5.Peter, J. et al. Contribution of the Cholinergic System to Verbal Memory Performance in Mild Cognitive Impairment. J. Alzheimers Dis. 53, 991–1001 (2016).Fig 1. Plots showing mean group outcome values of modeled variables for baseline and follow up visit (time interval of 1.5 years (range: 15-18 months); Significanteffects are shown in red. Error bars show upper and lower 95 % - CI around the group’s mean. The model includes a fixed effect controlling for age.Verbal episodic memory dysfunction in MCI is linked primarily toneurodegeneration in the hippocampus and not to changes in thecholinergic system. Thus, both current memory performance5 andthe longitudinal change in episodic memory is related to severity ofhippocampal damage in MCI.OutlookDiscussionMethod

Predicting verbal episodic memory changes with longitudinal measures of brain atrophy in mild cognitive impairment

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Predicting verbal episodic memory changes with longitudinal measures of brain atrophy in mild cognitive impairment

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