According to recent European Directives 2009/28/EC and FQD 2009/30/EC, the promoting of biofuels use and their sustainability appears to be an interesting and relevant topic. Biodiesel has an important role because of his availability and standardization but some technical limits, significantly affecting the operability, have been observed in the mixture of it with diesel fuel. Microbial growth and poor cold flow properties impacted on the industry and created several issues on the correct supply operations in retail site. A particular feature of the work is the Supply Chain Management approach in which the Shell Italia PQ Team took up the issue. The management approach to the problem made it possible, through careful analytical study of existing data, to trace the causes, identity the impacts, solve it and generate operational procedures to safeguard the quality of oil products. The analysis and subsequent actions have covered all the key points of Shell Italia’s supply chain and required a deep study on biodiesel production processes, on the physical and chemical properties of the B7 mixture and on the associated European regulations