Influência da clareação dentária sobre o tecido pulpar de ratos diabéticos: aspectos histológicos e imunológicos

Abstract

Objective: To evaluate the influence of dental bleaching on the pulp tissue of diabetic rats over the histological aspects and proinflammatory cytokines regulation. Methods: Twenty-eight Wistar rats were divided into four groups: (N) normoglycemic; (NBle) normoglycemic-bleached, (D) diabetic, (DBle) diabeticbleached. Fourteen animals reveiced a 150mg/kg dose of alloxan for diabetes induction, via IM. After 3 days, all animals were anesthetized and the dental bleaching performed using 35% hydrogen peroxide (H2O2) gel (Whiteness HP Maxx) in the right maxillary molars for 30 minutes. Left upper molars were used as control. Two and 30 days after the animals were euthanized, and the hemi-maxillae processed for histological and histochemistry analysis. Qualitative analyses were performed for inflammatory reaction and immunolabelling, and quantitative for pulp chamber area reduction and collagen fibers. The results were submitted to statistical analysis (p0.05). However, there was a significant difference when NBle and DBle groups were compared with regards to reduction of the pulp chamber area due the presence of reactionary dentin deposition (p0.05). Entretanto, houve diferença significante quando comparados os grupos NCla e DCla em relação à redução da área da câmara pulpar devido a deposição de dentina reacionária...Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES