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Correction of destructive changes in connective tissues of different organs during chronic nitrate and fluoride intoxication by nanosized silica oxide
Authors
O. Ye. Akimov
V. O. Kostenko
I. O. Kovalova
Publication date
24 May 2019
Publisher
Doi
Cite
Abstract
Akimov O. Ye., Kovalova I. O., Kostenko V. O. Correction of destructive changes in connective tissues of different organs during chronic nitrate and fluoride intoxication by nanosized silica oxide. Journal of Education, Health and Sport. 2019;9(5):547-555. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3238594 http://ojs.ukw.edu.pl/index.php/johs/article/view/6997 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 29.04.2019. Revised: 15.05.2019. Accepted: 24.05.2019. "XVIII V. V. Podvysotskiy Readings" May, 21-22, Odessa Materials of conference CORRECTION OF DESTRUCTIVE CHANGES IN CONNECTIVE TISSUES OF DIFFERENT ORGANS DURING CHRONIC NITRATE AND FLUORIDE INTOXICATION BY NANOSIZED SILICA OXIDE O. Ye. Akimov, I. O. Kovalova, V. O. Kostenko Ukrainian Medical Stomatological Academy, Poltava, Ukraine Abstract This experiment carried on 35 white Wistar rats aimed at studying the markers of connective tissue destruction during chronic nitrate-fluoride intoxication and its correction by nanosized silica oxide. It has been found out that co-administration of sodium fluoride (10 mg/kg body weight) and sodium nitrate (500 mg/kg of body weight) for 30 days increases the total content of glycosaminoglycans (GAG), heparin/heparan and keratan/dermatan fractions, as well as content of chondroitin fraction and concentration of L-oxyproline in the gastric mucosa. The content of N-acetylneuraminic acid (NANA), free L-oxyproline and gexuronic acids are increased in femoral bone and lumbar vertebrae. These changes point to depolymerization of componets of organic connective tissues matrix (collagen, glycoproteins, proteoglycans). Application of nanosized silica oxide suspension under conditions of chronic nitrate-fluoride intoxication reduces the total GAG content, keratan / dermatane fraction ratio, chondroitin fraction and L-oxyproline concentration in the gastric mucosa. We also observed a decrease in free L-oxyproline concentration, gexuronic acids and NANA content in femoral bone and vertebrae. The results allowed us to conclude that chronic nitrate-fluoride intoxication leads to the destruction of connective tissue components in different organs (gastric mucous membrane, femoral bones and vertebrae). Usage of nanosized silica oxide under conditions of chronic nitrate-fluoride intoxication reduces the destruction of connective tissue in these structures. Key words: nitrates, fluorides, nanosized silica oxide, chronic intoxication, gastric mucosa, bone
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