Los últimos avances en matemáticas en el campo de geometría fractal han permitido el surgimiento de una gran variedad de aplicaciones informáticas útiles para la representación de conjuntos fractales. Este trabajo pretende presentar a IFSConstruction Kit como una opción para construir fractales con base en los sistemas de funciones iteradas

Basso, LA

Canduri, F

de Azevedo, WF

dos Santos, DM

dos Santos, G

Fonseca, IO

Mendes, MA

Olivieri, JR

Palma, MS

Renard, G

Santos, DS

Silva, Rafael G

University of St. Andrews - Pure

Docking and small angle X-ray scattering studies of purine nucleoside phosphorylase

Docking simulations have been used to assess protein complexes with some success. Small angle X-ray scattering (SAXS) is a well-established technique to investigate protein spatial configuration. This work describes the integration of geometric docking with SAXS to investigate the quaternary structure of recombinant human purine nucleoside phosphorylase (PNP). This enzyme catalyzes the reversible phosphorolysis of N-ribosidic bonds of purine nucleosides and deoxynucleosides. A genetic deficiency due to mutations in the gene encoding for PNP causes gradual decrease in T-cell immunity. Inappropriate activation of T-cells has been implicated in several clinically relevant human conditions such as transplant rejection, rheumatoid arthritis, lupus, and T-cell lymphomas. PNP is therefore a target for inhibitor development aiming at T-cell immune response modulation and has been submitted to extensive structure-based drug design. The present analysis confirms the trimeric structure observed in the crystal. The potential application of the present procedure to other systems is discussed. (C) 2003 Elsevier B.V. All rights reserved

de Azevedo, W. F.

dos Santos, G. C.

dos Santos, D. M.

Canduri, F.

Silva, R. G.

Basso, L. A.

Renard, G.

da Fonseca, I. O.

Mendes, M. A.

Palma, Mario Sergio

Santos, D. S.

Acervo Digital da Unesp

Rivera, Luis Carlos

Funes