Juvenile granulosa cell tumor of the ovary: Imprint cytology findings
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Abstract
We present here the cytologic findings obtained from imprint smears of a juvenile granulosa cell tumor (GCT) of the ovary, a rare tumor in the sex cord/stromal tumor group that occurs predominantly in children and young adults.4 To our knowledge, the cytologic findings of juvenile GCT have been documented in only one case in the English-language literature.3 A girl aged 6 years, 7 months, presented with spotty vaginal bleeding, enlargement of both breasts and growth of fine pubic hair. A laparotomy disclosed a 10\ua56\ua55-cm, solid tumor replacing the right ovary (FIGO stage Iai). A right salpingo-oophorectomy was performed, and the patient recovered uneventfully. Direct imprint smear specimens were taken from the freshly cut surface of the tumor. The tumor cells formed many large, cellular aggregates with an irregular shape, and single cells were scattered in between (Figure 1). Cellular cohesiveness was of a moderate degree. The nuclei of the tumor cells were large and round or elliptical. Nuclear atypism and pleomorphism were not remarkable. The nuclear contour was smooth, and coffee bean-like nuclear grooves or indentations were not observed (Figure 2). Nuclear chromatin was of moderate amount and finely stippled. A few small but distinct nucleoli were found. The cytoplasm was pale and moderate in amount, and its border was indistinct